PVRL2
(Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
Protein-Typ
Recombinant
Biologische Aktivität
Active
Proteineigenschaft
AA 32-360
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses PVRL2 Protein ist gelabelt mit His tag.
Applikation
Functional Studies (Func)
Sequenz
AA 32-360
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.4 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).