PGLYRP1 Protein (His tag)

Produktnummer ABIN7320401

Produktdetails

Target: PGLYRP1 (Peptidoglycan Recognition Protein 1 (PGLYRP1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PGLYRP1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse PGLYRP1/PGRP-S Protein (His Tag)

Sequenz: Met 1-Glu 182

Produktmerkmale: A DNA sequence encoding the mouse PGLYRP (O88593) (Met 1-Glu 182) was expressed, with a C-terminal polyhistidine tag

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from PBS, pH 7.4, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PGLYRP1 (Peptidoglycan Recognition Protein 1 (PGLYRP1))

Andere Bezeichnung: PGLYRP1/PGRP-S (PGLYRP1 Produkte)

Synonyme: PGLYRP1 Protein, PGLYRP Protein, pgrp Protein, tag7 Protein, pgrps Protein, pglyrp Protein, pgrp-s Protein, tnfsf3l Protein, MGC108330 Protein, MGC108469 Protein, PGRP-SC1a Protein, si:dkey-113g17.4 Protein, si:ch211-202c21.3 Protein, PGRP Protein, PGRP-S Protein, PGRPS Protein, TAG7 Protein, TNFSF3L Protein, Pglyrp Protein, Tag7 Protein, Tasg7 Protein, Tnfsf3l Protein, Pgrp Protein, peptidoglycan recognition protein 1 Protein, peptidoglycan recognition protein 1 L homeolog Protein, peptidoglycan recognition protein 5 Protein, PGLYRP1 Protein, pglyrp1.L Protein, pglyrp1 Protein, pglyrp5 Protein, Pglyrp1 Protein

Hintergrund:

Background: Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1 / PGLYRP is highly expressed in bone marrow. It is weakly expressed in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. PGLYRP1 / PGLYRP is a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. It has bactericidal activity towards Gram-positive bacteria. PGLYRP1 / PGLYRP may kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. It binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Peptidoglycan recognition proteins ( PGRPs or PGLYRPs ) are innate immunity proteins that are conserved from insects to mammals, recognize bacterial peptidoglycan, and function in antibacterial immunity and inflammation. Mammals have four PGRPs: PGLYRP1, PGLYRP2, PGLYRP3, and PGLYRP4. They are secreted proteins expressed in polymorphonuclear leukocytes ( PGLYRP1 ), liver ( PGLYRP2 ), or on body surfaces, mucous membranes, and in secretions (saliva, sweat) (PGLYRP3 and PGLYRP4). All PGRPs recognize bacterial peptidoglycan. The PGRPs likely play a role both in antibacterial defenses and several inflammatory diseases. They modulate local inflammatory responses in tissues (such as arthritic joints) and there is evidence for association of PGRPs with inflammatory diseases, such as psoriasis.

Synonym: Pglyrp;PGRP;PGRP-S;Tag7;Tasg7;Tnfsf3l

Molekulargewicht: 20.2 kDa

UniProt: O88593

Pathways: Activation of Innate immune Response