MAPK13 Protein (GST tag)

Produktnummer ABIN7317773

Produktdetails

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses MAPK13 Protein ist gelabelt mit GST tag.

Verwendungszweck: Recombinant Human p38 delta/MAPK13 Protein (GST Tag)

Sequenz: Met 1-Leu 365

Produktmerkmale: A DNA sequence encoding the full length of human MAPK13 (O15264) (Met 1-Leu 365) was fused with the GST tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 10 % glycerol, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Andere Bezeichnung: p38 delta/MAPK13 (MAPK13 Produkte)

Synonyme: F24B9.3 Protein, F24B9_3 Protein, MAPK 13 Protein, MAPK-13 Protein, PRKM13 Protein, SAPK4 Protein, p38delta Protein, Serk4 Protein, Prkm13 Protein, sapk4 Protein, prkm13 Protein, Protein kinase superfamily protein Protein, mitogen-activated protein kinase 13 Protein, mitogen activated protein kinase 13 Protein, ATMPK13 Protein, MAPK13 Protein, Mapk13 Protein, mapk13 Protein

Hintergrund:

Background: The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. p38 delta, also known as MAPK13, is a regulator of differentiation-dependent gene expression in keratinocytes, and been as a regulator of surface epithelia differentiation and apoptosis. p38 delta protein is upregulated in Cholangiocarcinoma (CC) relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissues. p38 delta is important for motility and invasion of CC cells, suggesting that p38 delta may play an important role in CC metastasis. p38 delta is expressed in the epidermis, suggesting a role for p38 delta in regulating differentiation. p38 delta is the major p38 isoform driving suprabasal involucrin gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. p38 delta has important role in promoting cell proliferation and tumor development in epidermis and may have therapeutic implication for skin cancer.

Synonym: MAPK-13,MAPK13,p38delta,PRKM13,SAPK4

Molekulargewicht: 68.4 kDa

UniProt: O15264

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Hepatitis C, BCR Signaling, S100 Proteine