IL13 Receptor alpha 1 Protein (Fc Tag)

Produktnummer ABIN7196394

Produktdetails

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL13 Receptor alpha 1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Rat IL13RA1 Protein (Fc Tag)

Sequenz: Met1-Thr342

Produktmerkmale: A DNA sequence encoding the rat IL13RA1 (Q561K3) (Met1-Thr342) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Andere Bezeichnung: IL13RA1 (IL13RA1 Produkte)

Synonyme: CD213A2 Protein, CT19 Protein, IL-13R Protein, IL13BP Protein, CD213A1 Protein, IL-13Ra Protein, NR4 Protein, AI882074 Protein, CD213a1 Protein, IL-13r[a] Protein, Il13ra Protein, IL13RA1 Protein, il-13ra1 Protein, si:ch211-150g2.2 Protein, interleukin 13 receptor subunit alpha 2 Protein, interleukin 13 receptor subunit alpha 1 Protein, interleukin 13 receptor, alpha 1 Protein, interleukin 13 receptor, alpha 1-like Protein, IL13RA2 Protein, IL13RA1 Protein, Il13ra1 Protein, il13ra1 Protein, LOC100360218 Protein

Hintergrund:

Background: Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Synonym: IL13RA1

Molekulargewicht: 62.9 kDa

UniProt: Q561K3

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response