FZD6 Protein (Fc Tag)

Produktnummer ABIN7317167

Produktdetails

Target: FZD6 (Frizzled Family Receptor 6 (FZD6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FZD6 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human Frizzled-6/FZD6 Protein (Fc Tag)

Sequenz: Met 1-Val153

Produktmerkmale: A DNA sequence encoding the human FZD6 (NP_003497.2) (Met1-Val153) was expressed with the Fc region of mouse IgG1 at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FZD6 (Frizzled Family Receptor 6 (FZD6))

Andere Bezeichnung: Frizzled-6/FZD6 (FZD6 Produkte)

Synonyme: zgc:65879 Protein, zgc:77440 Protein, fz6 Protein, frz6 Protein, Xfrz6 Protein, frizzled6 Protein, frizzled-6 Protein, FZ-6 Protein, FZ6 Protein, HFZ6 Protein, NDNC10 Protein, Frizzled-6 Protein, Fz6 Protein, frizzled class receptor 6 Protein, frizzled class receptor 6 S homeolog Protein, fzd6 Protein, fzd6.S Protein, FZD6 Protein, Fzd6 Protein

Hintergrund:

Background: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Synonym: FZ-6,FZ6,HFZ6,NDNC10

Molekulargewicht: 42 kDa

NCBI Accession: NP_003497

Pathways: WNT Signalweg, Tube Formation