EPH Receptor B3 Protein (EPHB3) (AA 585-998) (GST tag,His tag)

Produktnummer ABIN7195551

Produktdetails

Target: EPH Receptor B3 (EPHB3)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 585-998

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses EPH Receptor B3 Protein ist gelabelt mit GST tag,His tag.

Verwendungszweck: Recombinant Human EphB3/HEK2 Protein (aa 585-998, His & GST Tag)(Active)

Sequenz: Gln 585-Val 998

Produktmerkmale: A DNA sequence encoding the human EPHB3 (P54753) (Gln585-Val998) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 90 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: EPH Receptor B3 (EPHB3)

Andere Bezeichnung: EphB3/HEK2 (EPHB3 Produkte)

Synonyme: tck Protein, MGC83457 Protein, EPHB3 Protein, ETK2 Protein, HEK2 Protein, TYRO6 Protein, AW456895 Protein, Cek10 Protein, Etk2 Protein, MDK5 Protein, Sek4 Protein, Tyro6 Protein, CEK10 Protein, EK10 Protein, ek3 Protein, ephb3 Protein, fc62d03 Protein, rtk3 Protein, wu:fc62d03 Protein, zek3 Protein, EPH receptor B3 Protein, EPH receptor B3 L homeolog Protein, Eph receptor B3 Protein, eph receptor B3a Protein, Eph receptor tyrosine kinase Protein, EPHB3 Protein, ephb3.L Protein, ephb3 Protein, Ephb3 Protein, ephb3a Protein

Hintergrund:

Background: Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

Synonym: ETK2,HEK2,TYRO6

Molekulargewicht: 74.7 kDa

UniProt: P54753

Pathways: RTK Signalweg