CDKN1B Protein (His tag)
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- Target Alle CDKN1B Proteine anzeigen
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses CDKN1B Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human CDKN1B Protein (His Tag)
- Sequenz
- Met 1-Thr198
- Produktmerkmale
- Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B is produced by our E.coli expression system and the target gene encoding Met1-Thr198 is expressed with a 6His tag at the N-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CDKN1B Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Andere Bezeichnung
- CDKN1B (CDKN1B Produkte)
- Synonyme
- CDKN4 Protein, KIP1 Protein, MEN1B Protein, MEN4 Protein, P27KIP1 Protein, cdkn1b Protein, sb:cb611 Protein, wu:fb63g10 Protein, wu:fb64g10 Protein, wu:fe18e03 Protein, CDKN1B Protein, Kip1 Protein, p27 Protein, FAM14D Protein, ISG12 Protein, ISG12A Protein, P27 Protein, Cdki1b Protein, AA408329 Protein, AI843786 Protein, p27Kip1 Protein, cdkn1bl Protein, cyclin dependent kinase inhibitor 1B Protein, cyclin-dependent kinase inhibitor 1Bb Protein, interferon alpha inducible protein 27 Protein, cyclin-dependent kinase inhibitor 1B Protein, cyclin-dependent kinase inhibitor 1Ba Protein, CDKN1B Protein, cdkn1bb Protein, IFI27 Protein, Cdkn1b Protein, cdkn1ba Protein
- Hintergrund
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Background: Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
Synonym: Cyclin-Dependent Kinase Inhibitor 1B, Cyclin-Dependent Kinase Inhibitor p27, p27Kip1, CDKN1B, KIP1
- Molekulargewicht
- 24.2 kDa
- UniProt
- P46527
- Pathways
- Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagie
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