BRCA2 Protein (His tag)

Produktnummer ABIN7319945

Produktdetails

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses BRCA2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human BRCA2 Protein (His Tag)

Sequenz: Thr2350-Val2545

Produktmerkmale: A DNA sequence encoding the Human BRCA2 (P51587-1) (Thr2350-Val2545) was expressed with a polyhistidine tag at the N-terminus.

Reinheit: >85 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Immunogen(E-AB-40288)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2 (BRCA2 Produkte)

Synonyme: BRCC2 Protein, BROVCA2 Protein, FACD Protein, FAD Protein, FAD1 Protein, FANCB Protein, FANCD Protein, FANCD1 Protein, GLM3 Protein, PNCA2 Protein, 30169 Protein, BcDNA:SD25109 Protein, CG13583 Protein, CG13584 Protein, CG30169 Protein, Dmel\\CG30169 Protein, brca2 Protein, dmbrca2 Protein, fancd1 Protein, BRCA2 Protein, brcc2 Protein, brovca2 Protein, facd Protein, fad Protein, fad1 Protein, fancb Protein, AI256696 Protein, AW045498 Protein, Fancd1 Protein, RAB163 Protein, BRCA2, DNA repair associated Protein, Breast cancer 2, early onset homolog Protein, breast cancer 2, early onset Protein, BRCA2 Protein, Brca2 Protein, brca2 Protein, LOC584780 Protein

Hintergrund:

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Synonym: BRCA 2,BRCA1/BRCA2 containing complex subunit 2,Brca2,BRCA2,DNA repair associated,BRCA2,BRCC 2,BRCC2,Breast and ovarian cancer susceptibility gene early onset,breast and ovarian cancer susceptibility protein 2,Breast cancer 2 early onset,Breast Cancer 2 tumor suppressor,Breast cancer susceptibility protein BRCA2,Breast cancer type 2 susceptibility protein,BROVCA2,FACD,FAD 1,FAD,FAD1,FANCB,FANCD 1,FANCD,FANCD1,FANCD1 gene,Fanconi anemia complementation group D1,Fanconi anemia group D1 protein,GLM3,mutant BRCA2,OTTHUMP00000018803,OTTHUMP00000042401,PNCA2,XRCC11

Molekulargewicht: 22.1kDa

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location