SARS-CoV-2 Spike S2 Protein (BA.1 - Omicron) (His tag)

Produktnummer ABIN7125933

Produktdetails

Target: SARS-CoV-2 Spike S2

Protein-Typ: Recombinant

Proteineigenschaft: BA.1 - Omicron

Spezies: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SARS-CoV-2 Spike S2 Protein ist gelabelt mit His tag.

Verwendungszweck: SARS-CoV-2 Spike S2 protein, His Tag (BA.1/Omicron)

Sequenz: Ser 683 - Pro 1210

Produktmerkmale: SARS-CoV-2 S2 protein, His Tag (BA.1/Omicron) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1 (N764K, D796Y, N856K, Q954H, N969K, L981F, F817P, A892P, A899P, A942P, K986P, V987P). The mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.1; GISAID clade: GRA; Nextstrain clade: 21K). Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) are introduced to prevent the formation of aggregates in the course of protein production.

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 70-80 kDa under reducing (R) condition due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: SARS-CoV-2 Spike S2

Andere Bezeichnung: SARS-CoV-2 Spike S2 protein (SARS-CoV-2 Spike S2 Produkte)

Synonyme: E2 Protein, Surface Glycoprotein Protein, S Protein

Hintergrund: Synonyms: Spike,S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2,
It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Molekulargewicht: 59.9 kDa