Dieses SARS-CoV-2 Nucleocapsid Protein ist gelabelt mit His tag.
Verwendungszweck
SARS-CoV-2 Nucleocapsid protein, His Tag (BA.3*(S33V)/Omicron)
Sequenz
Met 1 - Ala 419
Produktmerkmale
SARS-CoV-2 Nucleocapsid protein, His Tag (BA.3*(S33V)/Omicron) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1 (P13L, GER 30-32del, S33V, R203K, G204R, S413R). The mutations (P13L, GER 30-32del, S33V, R203K, G204R, S413R) were identified in the SARS-CoV-2 Omicron variant (Pango lineage: BA.3, GISAID clade: GRA, Nextstrain clade: 21M).
SARS-CoV-2 N
Spezies: SARS Coronavirus-2 (SARS-CoV-2)
Wirt: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
Applikationshinweise
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.1 kDa. The protein migrates as 50-60 kDa under reducing (R) condition due to glycosylation.
Synonyms: Nucleocapsid protein,NP,Protein N, Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.