SARS-CoV-2 Spike Protein (P.1 - gamma, RBD) (Fc Tag)

Produktnummer ABIN6992401

Produktdetails

Target: SARS-CoV-2 Spike

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: P.1 - gamma, RBD

Spezies: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SARS-CoV-2 Spike Protein ist gelabelt mit Fc Tag.

Verwendungszweck: SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), Fc Tag (MALS verified)

Sequenz: AA 319-537

Produktmerkmale: SARS-CoV-2 S protein RBD (K417T,E484K,N501Y), Fc Tag is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (K417T, E484K, N501Y). The K417T, E484K, N501Y mutations were identified in the SARS-CoV-2 variant (known as P.1) which emerged in Brazil.

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Lagerung: -20 °C

Antigendetails

Target: SARS-CoV-2 Spike

Andere Bezeichnung: SARS-CoV-2 S protein (SARS-CoV-2 Spike Produkte)

Synonyme: E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein

Substanzklasse: Viral Protein

Hintergrund: It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Molekulargewicht: 51.1 kDa