SARS-CoV-2 Spike Protein (N501Y, RBD) (His tag)

Produktnummer ABIN6961041

Produktdetails

Target: SARS-CoV-2 Spike

Protein-Typ: Recombinant

Proteineigenschaft: N501Y, RBD

Spezies: SARS Coronavirus-2 (SARS-CoV-2)

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SARS-CoV-2 Spike Protein ist gelabelt mit His tag.

Verwendungszweck: SARS-CoV-2 Spike Protein RBD (Mammalian, N501Y, C-6His)

Produktmerkmale: Recombinant 2019-nCoV S-RBD is produced by Mammalian expression system and the target gene encoding Arg319-Ser541(N501Y) is expressed with a 6His tag at the C-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Antigendetails

Target: SARS-CoV-2 Spike

Andere Bezeichnung: SARS-CoV-2 S Protein (SARS-CoV-2 Spike Produkte)

Synonyme: E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein

Substanzklasse: Viral Protein

Hintergrund: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell during the initial stages of the infection process. The SARS-CoV-2 Spike Protein mediates the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. SARS-CoV-2 infects the human respiratory epithelial cells through interaction with the human ACE2 receptor. The Spike Protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The Spike Protein plays key a part in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.