TXNRD1 Protein (AA 161-647) (His tag)

Produktnummer ABIN667005

Produktdetails

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 161-647

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TXNRD1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: TXNRD1, 161-647aa, Human, His tag, E.coli

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5mg/ml (determined by Bradford assay)

Buffer: Liquid. In Phosphate Buffered Saline pH7.4 containing 10% glycerol

Lagerung: 4 °C

Antigendetails

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Andere Bezeichnung: TXNRD1 (TXNRD1 Produkte)

Synonyme: TrxR1 Protein, cb682 Protein, fb83a08 Protein, wu:fb83a08 Protein, GB14972 Protein, MGC85342 Protein, NADPH-dependent thioredoxin reductase C Protein, T32G6.20 Protein, T32G6_20 Protein, GRIM-12 Protein, TR Protein, TR1 Protein, TRXR1 Protein, TXNR Protein, Tr Protein, thioredoxin reductase 1 Protein, thioredoxin reductase 1 L homeolog Protein, NADPH-dependent thioredoxin reductase C Protein, ThioRedoXin Reductase Protein, TXNRD1 Protein, txnrd1 Protein, Trxr-1 Protein, txnrd1.L Protein, NTRC Protein, trxr-1 Protein, Txnrd1 Protein

Hintergrund: TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases. Recombinant human TXNRD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, GRIM 12, GRIM12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase GRIM 12, Thioredoxin reductase TR1, TR 1, TRXR 1, TXNRD 1. NCBI no.: NP_001087240

Molekulargewicht: 55.7 kDa (508aa), confirmed by MALDI-TOF

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis