NHEJ1 Protein (His tag)
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- Target Alle NHEJ1 Proteine anzeigen
- NHEJ1 (Nonhomologous End-Joining Factor 1 (NHEJ1))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses NHEJ1 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Aufreinigung
- purified by chromatography
- Reinheit
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product NHEJ1 Protein
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- Kommentare
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Synonyms: Non-homologous end-joining factor 1, XLF
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 20% glycerol,1 MM DTT
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Avoid repeated freezing and thawing cycles.
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- Target
- NHEJ1 (Nonhomologous End-Joining Factor 1 (NHEJ1))
- Andere Bezeichnung
- NHEJ1 (NHEJ1 Produkte)
- Synonyme
- NHEJ1 Protein, zgc:85657 Protein, XLF Protein, 1700029B21Rik Protein, cernunnos Protein, non-homologous end joining factor 1 Protein, non-homologous end joining factor 1 S homeolog Protein, solute carrier family 23 member 3 Protein, nonhomologous end-joining factor 1 Protein, NHEJ1 Protein, nhej1.S Protein, nhej1 Protein, SLC23A3 Protein, Nhej1 Protein
- Hintergrund
- Non-homologous end-joining factor 1, also known as NHEJ1, belongs to the XLF family. NHEJ1 was originally discovered as the protein mutated in five patients with growth retardation, microcephaly, and immunodeficiency. The protein is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Patients with NHEJ1 mutations also have immunodeficiency due to a defect in V(D)J recombination, which utilizes NHEJ to promote immune system diversity. XLF interacts with DNA ligase IV and XRCC4 and is thought to be involved in the ligation step of NHEJ. Recombinant human NHEJ1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molekulargewicht
- 27.8 kDa (247aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_079058
- Pathways
- DNA Reparatur
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