Cathepsin L Protein (AA 18-333) (His tag)

Produktnummer ABIN5854828

Produktdetails

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 18-333

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Cathepsin L Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSTLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV

Reinheit: > 85 % by SDS - PAGE

Endotoxin-Niveau: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl(  pH 8.0) containing 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Andere Bezeichnung: CTSL (CTSL1 Produkte)

Synonyme: CATL Protein, CTSL1 Protein, MEP Protein, 1190035F06Rik Protein, Ctsl1 Protein, fs Protein, nkt Protein, CATHL Protein, CatL Protein, Ctsl Protein, CTSL Protein, mep Protein, catl Protein, ctsl Protein, cpl-1 Protein, MGC80629 Protein, MGC107932 Protein, LOC663234 Protein, 26-29-p Protein, Cp1 Protein, si:dkey-121a11.6 Protein, CTSV Protein, catL Protein, cb15 Protein, ctsl1b Protein, hgg1 Protein, wu:fb30g09 Protein, zgc:92089 Protein, cathepsin L Protein, cathepsin V Protein, cathepsin L L homeolog Protein, cathepsin L1 Protein, Cathepsin L1 Protein, Cathepsin L Protein, testin gene Protein, cathepsin 12 Protein, cathepsin Lb Protein, cathepsin L.1 Protein, CTSL Protein, Ctsl Protein, CTSV Protein, ctsl.L Protein, ctsl Protein, LOC100008830 Protein, catl1 Protein, 26-29-p Protein, catl Protein, Tsp_11596 Protein, Testin Protein, cts12 Protein, LOC102156614 Protein, ctslb Protein, ctsl.1 Protein

Hintergrund: CTSL, also known as cathepsin L1 isoform 1, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. Recombinant Human CTSL protein was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 38.3kDa (339 aa) confirmed by MALDI-TOF

NCBI Accession: NP_001244901

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades