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Osteoactivin Protein (GPNMB) (AA 22-474) (His tag)
GPNMB
Spezies: Human
Wirt: Baculovirus infected Insect Cells
Recombinant
> 90 % by SDS - PAGE
SDS
Produktnummer ABIN5854811
Produktdetails
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Target
Alle Osteoactivin (GPNMB) Proteine anzeigen
Osteoactivin (GPNMB)
Protein-Typ
Recombinant
Proteineigenschaft
AA 22-474
Spezies
Alle Spezies für Osteoactivin Proteine
Human
Quelle
Alle Expressionssysteme für Osteoactivin Proteine
Baculovirus infected Insect Cells
Aufreinigungstag / Konjugat
Dieses Osteoactivin Protein ist gelabelt mit His tag.
Applikation
SDS-PAGE (SDS)
Sequenz
ADPAKRFHDV LGNERPSAYM REHNQLNGWS SDENDWNEKL YPVWKRGDMR WKNSWKGGRV QAVLTSDSPA LVGSNITFAV NLIFPRCQKE DANGNIVYEK NCRNEAGLSA DPYVYNWTAW SEDSDGENGT GQSHHNVFPD GKPFPHHPGW RRWNFIYVFH TLGQYFQKLG RCSVRVSVNT ANVTLGPQLM EVTVYRRHGR AYVPIAQVKD VYVVTDQIPV FVTMFQKNDR NSSDETFLKD LPIMFDVLIH DPSHFLNYST INYKWSFGDN TGLFVSTNHT VNHTYVLNGT FSLNLTVKAA APGPCPPPPP PPRPSKPTPS LGPAGDNPLE LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPESSLI DFVVTCQGSI PTEVCTIISD PTCEITQNTV CSPVDVDEMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS TLISVPHHHH HH
Reinheit
> 90 % by SDS - PAGE
Endotoxin-Niveau
< 1.0 EU per 1 microgram of protein (determined by LAL method)
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
0.5 mg/mL
Buffer
Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
Lagerung
4 °C,-20 °C,-80 °C
Informationen zur Lagerung
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Antigendetails
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Target
Osteoactivin (GPNMB)
Andere Bezeichnung
GPNMB (GPNMB Produkte )
Synonyme
HGFIN Protein, NMB Protein, DC-HIL Protein, Dchil Protein, ipd Protein, glycoprotein nmb Protein, glycoprotein (transmembrane) nmb Protein, glycoprotein nmb L homeolog Protein, Gpnmb Protein, GPNMB Protein, gpnmb.L Protein
Hintergrund
GPNMB, also known as glycoprotein nmb, is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. This protein participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. It may be involved in growth delay and reduction of metastatic potential. Recombinant human GPNMB protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Molekulargewicht
51.8kDa (462aa) 50-70KDa (SDS-PAGE under reducing conditions.)
NCBI Accession
NP_002501
UniProt
Q14956
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