APCS Protein (AA 311-391) (GST tag)

Produktnummer ABIN5710163

Produktdetails

Target: APCS (Amyloid P Component, Serum (APCS))

Protein-Typ: Recombinant

Proteineigenschaft: AA 311-391

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses APCS Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV VDTYGSSILS ILLEEVSPEL VCSMLHLCSG T

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: APCS (Amyloid P Component, Serum (APCS))

Andere Bezeichnung: SAP (APCS Produkte)

Synonyme: PTX2 Protein, SAP Protein, Sap Protein, APCS Protein, FP Protein, SAP(FP) Protein, apcs Protein, ptx2 Protein, sap Protein, amyloid P component, serum Protein, serum amyloid P-component Protein, amyloid P component, serum protein L homeolog Protein, APCS Protein, Apcs Protein, apcs.L Protein

Hintergrund: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.

Molekulargewicht: 36.4 kDa

UniProt: P07602