APCS Protein (His tag)

Produktnummer ABIN7320402

Produktdetails

Target: APCS (Amyloid P Component, Serum (APCS))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses APCS Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse APCS/SAP Protein (His Tag)(Active)

Sequenz: Met 1-Glu 224

Produktmerkmale: A DNA sequence encoding the mouse APCS (NP_035448.2) (Met 1-Glu 224) precursor was expressed with a C-terminal polyhistidine tag.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA. Immobilized mouse APCS at 10 μg/ml (100 μl/well) can bind biotinylated human Fibronectin Fragment 2 with a linear ranger of 0.625-5 μg/ml.2. Measured by its ability to bind mouse CD64-AVI in a functional ELISA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: APCS (Amyloid P Component, Serum (APCS))

Andere Bezeichnung: APCS/SAP (APCS Produkte)

Synonyme: PTX2 Protein, SAP Protein, Sap Protein, APCS Protein, FP Protein, SAP(FP) Protein, apcs Protein, ptx2 Protein, sap Protein, amyloid P component, serum Protein, serum amyloid P-component Protein, amyloid P component, serum protein L homeolog Protein, APCS Protein, Apcs Protein, apcs.L Protein

Hintergrund:

Background: Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

Synonym: APCS; PTX2; SAP; 9.5S alpha-1-glycoprotein; Serum amyloid P; MGC88159; PTX2serum amyloid P-component; SAP pentaxin-related

Molekulargewicht: 25.3 kDa

NCBI Accession: NP_035448