RANKL Protein (AA 152-317, Soluble) (DYKDDDDK Tag)

Produktnummer ABIN2745824

Produktdetails

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Protein-Typ: Recombinant

Proteineigenschaft: Soluble, AA 152-317

Spezies: Human, Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses RANKL Protein ist gelabelt mit DYKDDDDK Tag.

Applikation: SDS-PAGE (SDS)

Spezifität: Binds to human and mouse RANK.

Kreuzreaktivität: Human, Maus

Produktmerkmale: Human RANKL (aa 152-317) is fused at the N-terminus to a FLAG®-tag.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with 100 μL sterile water.

Konzentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Andere Bezeichnung: RANKL (TNFSF11 Produkte)

Synonyme: CD254 Protein, ODF Protein, OPGL Protein, OPTB2 Protein, RANKL Protein, TRANCE Protein, hRANKL2 Protein, sOdf Protein, TNFSF11 Protein, Ly109l Protein, OPG Protein, Trance Protein, cd254 Protein, odf Protein, opgl Protein, optb2 Protein, rankl Protein, sodf Protein, tnfsf11 Protein, trance Protein, TNF superfamily member 11 Protein, tumor necrosis factor (ligand) superfamily, member 11 Protein, TNF receptor superfamily member 11b Protein, TNF superfamily member 11 L homeolog Protein, TNFSF11 Protein, Tnfsf11 Protein, TNFRSF11B Protein, tnfsf11.L Protein

Hintergrund: RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of breast cancer.

Molekulargewicht: ~28kDa (SDS-PAGE)

UniProt: O14788

Pathways: NF-kappaB Signalweg