Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag)

Details zu Produkt Nr. ABIN2731256, Anbieter: Anmelden zum Anzeigen
Proteinname
  • MTG8
  • si:ch211-232j17.1
  • wu:fi14b07
  • zgc:154044
  • AML1T1
  • CBFA2T1
  • CDR
  • ETO
  • ZMYND2
  • Cbfa2t1h
  • Cbfa2t1
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
  • RUNX1 translocation partner 1 L homeolog
  • RUNX1 translocation partner 1
  • runx1t1
  • runx1t1.L
  • RUNX1T1
  • Runx1t1
Proteineigenschaft
Transcript Variant 4
1
1
1
1
1
1
1
Spezies
Human
4
1
Quelle
HEK-293 Cells
2
2
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses RUNX1T1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
Applikation
Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Spezifität Optimal preservation of protein structure, post-translational modifications and functions.
Produktmerkmale
  • Recombinant human RUNX1T1 (transcript variant 4) protein expressed in HEK293 cells.
  • Produced with end-sequenced ORF clone
Reinheit > 80 % as determined by SDS-PAGE and Coomassie blue staining
Proteinname
Hintergrund This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(821)(q22q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5&apos-region of the runt-related transcription factor 1 gene fused to the 3&apos-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
Molekulargewicht 63 kDa
NCBI Accession NP_783554
Applikations-hinweise Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays
Kommentare

The tag is located at the C-terminal.

Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration > 50 μg/mL
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Lagerung -80 °C
Informationen zur Lagerung Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
Bilder des Herstellers
Western Blotting (WB) image for Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag) (ABIN2731256) Validation with Western Blot
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