RUNX1T1 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2731257

Produktdetails

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 3

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses RUNX1T1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human RUNX1T1 (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Andere Bezeichnung: Runx1t1 (RUNX1T1 Produkte)

Synonyme: MTG8 Protein, si:ch211-232j17.1 Protein, wu:fi14b07 Protein, zgc:154044 Protein, AML1T1 Protein, CBFA2T1 Protein, CDR Protein, ETO Protein, ZMYND2 Protein, Cbfa2t1h Protein, Cbfa2t1 Protein, runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Protein, RUNX1 translocation partner 1 L homeolog Protein, RUNX1 translocation partner 1 Protein, runx1t1 Protein, runx1t1.L Protein, RUNX1T1 Protein, Runx1t1 Protein

Hintergrund: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(821)(q22q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5&apos-region of the runt-related transcription factor 1 gene fused to the 3&apos-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 63 kDa

NCBI Accession: NP_783553