Paxillin Protein (PXN) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2728328

Produktdetails

Target: Paxillin (PXN)

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Paxillin Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Paxillin / PXN (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Referenzen

Sharifi, Mowers, Drake, Collier, Chen, Zamora, Mui, Macleod: "Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3." in: Cell reports, Vol. 15, Issue 8, pp. 1660-72, (2016) (PubMed).

Wilson, Bradley, Shaw, Wagenmakers: "Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature." in: Histochemistry and cell biology, Vol. 142, Issue 3, pp. 245-56, (2014) (PubMed).

Antigendetails

Target: Paxillin (PXN)

Andere Bezeichnung: Paxillin,pxn (PXN Produkte)

Synonyme: AW108311 Protein, AW123232 Protein, Pax Protein, CG18061 Protein, CG18576 Protein, CG31794 Protein, CT40481 Protein, CT42454 Protein, DPaxillin Protein, DPxn Protein, DPxn37 Protein, Dmel\\CG31794 Protein, Dpax Protein, DpaxA Protein, PDLP Protein, dPax Protein, pax Protein, wu:fw71f12 Protein, PXN Protein, LOC100220858 Protein, paxillin Protein, Paxillin Protein, paxillin S homeolog Protein, paxillin a Protein, PXN Protein, Pxn Protein, Pax Protein, pxn.S Protein, pxna Protein, LOC696336 Protein, pxn Protein

Hintergrund: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).

Molekulargewicht: 60.8 kDa

NCBI Accession: NP_002850

Pathways: MAPK Signalweg, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling