INPP5D Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2723485

Produktdetails

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses INPP5D Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human INPP5D (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Andere Bezeichnung: Inpp5d (INPP5D Produkte)

Synonyme: INPP5D Protein, 256.t00004 Protein, 13.t00027 Protein, ship Protein, ship1 Protein, AI323613 Protein, SHIP Protein, SHIP-1 Protein, SHIP1 Protein, s-SHIP Protein, SIP-145 Protein, hp51CN Protein, inositol polyphosphate-5-phosphatase D Protein, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Protein, inositol polyphosphate 5-phosphatase Protein, inositol polyphosphate-5-phosphatase D L homeolog Protein, INPP5D Protein, LOC100446045 Protein, inpp5d Protein, EHI_159880 Protein, EHI_153490 Protein, inpp5d.L Protein, LOC100380693 Protein, Inpp5d Protein

Hintergrund: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Molekulargewicht: 133 kDa

NCBI Accession: NP_005532

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling, Warburg Effekt