DUSP4 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2719838

Produktdetails

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses DUSP4 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human DUSP4 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Andere Bezeichnung: Dusp4 (DUSP4 Produkte)

Synonyme: zgc:55423 Protein, DUSP4 Protein, typ Protein, hvh2 Protein, mkp2 Protein, mkp-2 Protein, MGC131045 Protein, HVH2 Protein, MKP-2 Protein, MKP2 Protein, TYP Protein, 2700078F24Rik Protein, AI844617 Protein, BB104621 Protein, E130306H24Rik Protein, Mkp-2 Protein, Mkp2 Protein, dual specificity phosphatase 4 Protein, dual specificity phosphatase 4 S homeolog Protein, dusp4 Protein, DUSP4 Protein, dusp4.S Protein, Dusp4 Protein

Hintergrund: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Molekulargewicht: 32.8 kDa

NCBI Accession: NP_476499

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades