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DUSP4 Produkte

(Dual Specificity Phosphatase 4, DUSP4)

Kategorien

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008].

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Ausgewählte DUSP4 Kategorien

DUSP4 Antikörper

High quality antibodies with extensive validation data.

DUSP4 ELISA Kits

Reliable ELISA kits for a wide range of species.

DUSP4 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene DUSP4 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätHuman, Mouse, Rat
ApplikationELISA, ICC, IF, IHC, WB
Validierungen
  • collections(4)
Kat. Nr.ABIN6263269
Menge100 μL
ReaktivitätHuman
ApplikationIF, ELISA, WB
Validierungen
  • collections(4)
Kat. Nr.ABIN515105
Menge100 μg
ReaktivitätHuman, Mouse
ApplikationIHC (p), WB
Validierungen
  • collections(3)
Kat. Nr.ABIN392861
Menge400 μL

Empfohlene DUSP4 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätHuman
Analytical MethodQuantitative Sandwich ELISA
Validierungen
  • collections(1)
Kat. Nr.ABIN6966428
Menge96 tests
ReaktivitätHuman, Mouse, Rat
Analytical MethodQualitative Cell ELISA
Validierungen
Kat. Nr.ABIN5648052
Menge96 tests
ReaktivitätChicken
Analytical Method
Validierungen
Kat. Nr.ABIN1130804
Menge96 tests

Empfohlene DUSP4 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätHuman
SourceInsect Cells
Validierungen
  • collections(1)
Kat. Nr.ABIN3079077
Menge1 mg
ReaktivitätMouse
SourceInsect Cells
Validierungen
  • collections(1)
Kat. Nr.ABIN3124597
Menge1 mg
ReaktivitätHuman
SourceWheat germ
Validierungen
  • collections(1)
Kat. Nr.ABIN1352136
Menge10 μg

Neueste Publikationen zu unseren DUSP4 Produkten

Jung, Lee, Kim, Ahn, Park, Im: "Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency." in: Scientific reports, Vol. 6, pp. 33035, 2016 (PubMed).

Barajas-Espinosa, Basye, Angelos, Chen: "Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress." in: Free radical biology & medicine, Vol. 89, pp. 170-81, 2015 (PubMed).

Manzano, Martinez-Navarro, Forteza, Brugarolas: "Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers." in: International journal of oncology, Vol. 45, Issue 6, pp. 2250-66, 2014 (PubMed).

Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, 2014 (PubMed).

Lee, Huang, Lee, Lee, Ryu, Kim, Kim, Kim, Joung, Kim, Shong, Jo: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, 2012 (PubMed).

Keyse: "Dual-specificity MAP kinase phosphatases (MKPs) and cancer." in: Cancer metastasis reviews, Vol. 27, Issue 2, pp. 253-61, 2008 (PubMed).

Teng, Huang, Meng: "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress." in: The Journal of biological chemistry, Vol. 282, Issue 39, pp. 28395-407, 2007 (PubMed).

Shen, Wang, Wu, Zhurkin, Yin: "Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis." in: Cancer research, Vol. 66, Issue 12, pp. 6033-9, 2006 (PubMed).

Berasi, Huard, Li, Shih, Sun, Zhong, Paulsen, Brown, Gimeno, Martinez: "Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase." in: The Journal of biological chemistry, Vol. 281, Issue 37, pp. 27167-77, 2006 (PubMed).

Black, Walker, Clark, MacLaren, Gillespie: "Cell transformation by v-Jun deactivates ERK MAP kinase signalling." in: Oncogene, Vol. 21, Issue 42, pp. 6540-8, 2002 (PubMed).

Synonyme und alternative Namen zu DUSP4

dual specificity phosphatase 4 (dusp4), dual specificity phosphatase 4 (DUSP4), dual specificity phosphatase 4 S homeolog (dusp4.S), dual specificity phosphatase 4 (Dusp4), 2700078F24Rik, AI844617, BB104621, DUSP4, E130306H24Rik, hvh2, HVH2, MGC131045, MKP-2, Mkp-2, mkp-2, Mkp2, mkp2, MKP2, TYP, typ, zgc:55423

Gen-IDs für verschiedene Spezies

GENE ID SPEZIES
394146 Danio rerio
464497 Pan troglodytes
540380 Bos taurus
548863 Xenopus (Silurana) tropicalis
734786 Xenopus laevis
100223600 Taeniopygia guttata
1846 Homo sapiens
319520 Mus musculus
60587 Rattus norvegicus
395642 Gallus gallus

Bezeichner auf Proteinebene für DUSP4

  • dual specificity protein phosphatase 4
  • dual specificity phosphatase 4
  • MAP kinase phosphatase 2
  • VH1 homologous phosphatase 2
  • dual specificity protein phosphatase hVH2
  • mitogen-activated protein kinase phosphatase 2
  • serine/threonine specific protein phosphatase
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