DUSP10 Produkte
(Dual Specificity Phosphatase 10 (DUSP10))
Kategorien
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique\; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte DUSP10 Kategorien
DUSP10 Antikörper
High quality antibodies with extensive validation data.
DUSP10 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DUSP10 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC (p)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN545062
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN564881
Menge
50 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), ICC, IF
Validierungen
- (3)
Kat. Nr.
ABIN2855915
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene DUSP10 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6203849
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DUSP10 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1352098
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN668018
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3079098
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DUSP10 Produkten
: "mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma." in: Genes & cancer, Vol. 5, Issue 11-12, pp. 393-406, (2015) (PubMed).: "Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML." in: The Journal of experimental medicine, Vol. 211, Issue 6, pp. 1093-108, (2014) (PubMed).
: "Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation." in: Cancer research, Vol. 71, Issue 16, pp. 5535-45, (2011) (PubMed).
: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).
: "Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells." in: American journal of physiology. Renal physiology, Vol. 297, Issue 6, pp. F1622-31, (2009) (PubMed).
: "Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 1, pp. 113-23, (2008) (PubMed).
: "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress." in: The Journal of biological chemistry, Vol. 282, Issue 39, pp. 28395-407, (2007) (PubMed).
: "JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity." in: Molecular and cellular biology, Vol. 25, Issue 19, pp. 8619-30, (2005) (PubMed).
: "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases." in: Oncogene, Vol. 18, Issue 50, pp. 6981-8, (2000) (PubMed).
Synonyme und alternative Namen zu DUSP10
dual specificity phosphatase 10 (DUSP10), dual specificity phosphatase 10 (Dusp10), 2610306G15Rik, AI158871, DUSP10, MKP-5, Mkp-5, MKP5, Mkp5Bezeichner auf Proteinebene für DUSP10
- dual specificity protein phosphatase 10
- dual specificity phosphatase 10
- dual specificity protein phosphatase 10-like
- dual specificity phosphatase MKP-5
- map kinase phosphatase 5
- mitogen-activated protein kinase phosphatase 5
- serine/threonine specific protein phosphatase
- MAP kinase phosphatase 5
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