POMC Protein (His tag)

Produktnummer ABIN2131235

Produktdetails

Target: POMC (Proopiomelanocortin (POMC))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses POMC Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: 27-267 amino acids: MGSSHHHHHH SSGLVPRGSH MWCLESSQCQ DLTTESNLLE CIRACKPDLS AETPMFPGNG DEQPLTENPR KYVMGHFRWD RFGRRNSSSS GSSGAGQKRE DVSAGEDCGP LPEGGPEPRS DGAKPGPREG KRSYSMEHFR WGKPVGKKRR PVKVYPNGAE DESAEAFPLE FKRELTGQRL REGDGPDGPA DDGAGAQADL EHSLLVAAEK KDEGPYRMEH FRWGSPPKDK RYGGFMTSEK SQTPLVTLFK NAIIKNAYKK GE

Produktmerkmale: Recombinant human POMC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Reinheit: > 85 % pure

Anwendungsinformationen

Applikationshinweise: POMC protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 1 mM DTT, 50 % glycerol and 0.2M NaCl.

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Antigendetails

Target: POMC (Proopiomelanocortin (POMC))

Andere Bezeichnung: POMC (POMC Produkte)

Synonyme: MSH Protein, ACTH Protein, pomc Protein, SI:bZ36D5.1 Protein, SI:bZ36D5.4 Protein, si:bz36d5.2 Protein, BE Protein, Beta-LPH Protein, Clip Protein, Gamma-LPH Protein, Npp Protein, Pomc-1 Protein, Pomc1 Protein, alpha-MSH Protein, alphaMSH Protein, beta-MSH Protein, gamma-MSH Protein, CLIP Protein, LPH Protein, NPP Protein, POC Protein, Pomc2 Protein, proopiomelanocortin a Protein, pro-opiomelanocortin-alpha Protein, proopiomelanocortin Protein, pomca Protein, Pomc Protein, POMC Protein

Hintergrund: Pro-opiomelanocortin preproprotein, also known as POMC, a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. It regulates the corticosteroid production in the adrenal cortex. Also, POMC is cleaved into ten hormone chains named NPP, gamma-MSH, ACTH, alpha-MSH, CLIP, Lipotropin beta, Lipotropin gamma, Beta-MSH, Beta-endorphin and Met-enkephalin. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency.

Molekulargewicht: 28.9 kDa (262aa), confirmed by MALDI-TOF(molecular weight on SDS-PAGE will appear higher)

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour