POMC Produkte
(Proopiomelanocortin (POMC))
Kategorien
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
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Ausgewählte POMC Kategorien
POMC Antikörper
High quality antibodies with extensive validation data.
POMC ELISA Kits
Reliable ELISA kits for a wide range of species.
POMC Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene POMC Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, FACS
Validierungen
- (6)
Kat. Nr.
ABIN185387
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP
Validierungen
- (5)
Kat. Nr.
ABIN519039
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, FACS, ICC
Validierungen
- (4)
Kat. Nr.
ABIN5542293
Menge
0.1 mg
Datenblatt
Datenblatt
Empfohlene POMC ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6958845
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969634
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969633
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene POMC Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1315730
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124601
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124600
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren POMC Produkten
: "A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 31, Issue 1-2, pp. 17-29, (2020) (PubMed).: "Hindbrain dorsal vagal complex AMPK controls hypothalamic gluco-regulatory transmitter and counter-regulatory hormone responses to hypoglycemia." in: Brain research bulletin, Vol. 144, pp. 171-179, (2019) (PubMed).
: "Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice." in: The Journal of biological chemistry, Vol. 294, Issue 13, pp. 4946-4955, (2019) (PubMed).
: "Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide." in: Neuroscience, Vol. 383, pp. 46-59, (2019) (PubMed).
: "Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity." in: The Journal of clinical investigation, Vol. 128, Issue 3, pp. 1125-1140, (2018) (PubMed).
: "Air-liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2." in: Cell death discovery, Vol. 3, pp. 17001, (2017) (PubMed).
: "A potential role for the secretogranin II-derived peptide EM66 in the hypothalamic regulation of feeding behaviour." in: Journal of neuroendocrinology, Vol. 29, Issue 3, (2017) (PubMed).
: "Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation." in: Neurochemical research, Vol. 41, Issue 9, pp. 2289-99, (2016) (PubMed).
: "Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying." in: BioMed research international, Vol. 2015, pp. 651048, (2016) (PubMed).
: "Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury." in: Neural regeneration research, Vol. 7, Issue 22, pp. 1729-35, (2015) (PubMed).
Synonyme und alternative Namen zu POMC
proopiomelanocortin a (pomca), pro-opiomelanocortin-alpha (Pomc), proopiomelanocortin (POMC), proopiomelanocortin (Pomc), ACTH, alpha-MSH, alphaMSH, BE, Beta-LPH, beta-MSH, Clip, CLIP, Gamma-LPH, gamma-MSH, LPH, MSH, Npp, NPP, POC, pomc, Pomc-1, Pomc1, Pomc2, SI:bZ36D5.1, si:bz36d5.2, SI:bZ36D5.4Bezeichner auf Proteinebene für POMC
- beta-endorphin
- pro-opiomelanocortin
- adrenal corticotropic hormone
- adrenocorticotropic hormone
- alpha-melanocyte stimulating hormone
- corticotropin-like intermediary peptide
- corticotropin-lipotropin
- melanotropin gamma
- met-enkephalin
- adrenocorticotropin
- alpha-MSH
- alpha-melanocyte-stimulating hormone
- beta-LPH
- beta-MSH
- beta-melanocyte-stimulating hormone
- gamma-LPH
- gamma-MSH
- lipotropin beta
- lipotropin gamma
- melanotropin alpha
- melanotropin beta
- opiomelanocortin prepropeptide
- pro-ACTH-endorphin
- proopiomelanocortin preproprotein
- pro-opiomelanocortin-alpha
- proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
- proopiomelanocortin, beta (endorphin, beta)
- proopoimelanocortin, beta (endorphin, beta)
- Corticotropin-lipotropin
- beta-lipotropin
- beta-melanocyte stimulating hormone
- pro-opiomelanocortin a-1
- pro-opiomelanocortin a-2
- pro-opiomelanocortin b-1
- pro-opiomelanocortin b-2
Haben Sie etwas anderes gesucht?
- POM121L2
- POM121L1P
- POM121L12
- POM121C
- POM121B
- POM121
- Polyubiquitin 3
- Polypyrimidine Tract-Binding Protein
- Polyprotein
- Polymyxin B
- Polychaetoid
- Polybromo 1
- Poly(A) Binding Protein, Nuclear 1-Like (Cytoplasmic)
- Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2
- Poly(A) Binding Protein, Cytoplasmic 1-Like
- Poly(A) Binding Protein, Cytoplasmic 1
- Poly-U Binding Splicing Factor 60KDa
- Poly-ADP-Ribose
- Poly Ubiquitin
- Poly Serum Antigen
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