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PKM Protein (AA 2-531) (His tag)

PKM Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN2115484
  • Target Alle PKM Proteine anzeigen
    PKM (Pyruvate Kinase M1/2 (PKM))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 2-531
    Spezies
    • 3
    • 2
    • 2
    Human
    Quelle
    • 4
    • 2
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses PKM Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human Pyruvate Kinase M2/PKM2 (N-6His)
    Sequenz
    MGSSHHHHHH SSGLVPRGSH MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV FASFIRKASD VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN AVLDGADCIM LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR LAPITSDPTE ATAVGAVEAS FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE AWAEDVDLRV NFAMNVGKAR GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P
    Produktmerkmale
    Recombinant Human PKM2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Pro531) of Human PKM2 fused with a 6His tag at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product PKM Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of PBS, pH 7.0, 10 % glycerol.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    PKM (Pyruvate Kinase M1/2 (PKM))
    Andere Bezeichnung
    Pyruvate Kinase PKM (PKM Produkte)
    Synonyme
    CTHBP Protein, OIP3 Protein, PK3 Protein, PKM2 Protein, TCB Protein, THBP1 Protein, AA414905 Protein, AL024370 Protein, AL024424 Protein, Pk-2 Protein, Pk-3 Protein, Pk3 Protein, Pkm2 Protein, PKM12 Protein, CG7070 Protein, Dmel\\CG7070 Protein, PYK Protein, Pyk Protein, cb1029 Protein, fj33f03 Protein, pkm2 Protein, pkm2a Protein, wu:fj33f03 Protein, MGC53388 Protein, PKM Protein, PK-S Protein, pk3 Protein, pkm2b Protein, zgc:92037 Protein, pyruvate kinase M1/2 Protein, pyruvate kinase, muscle Protein, Pyruvate kinase Protein, pyruvate kinase M1/2a Protein, pyruvate kinase PKM Protein, pyruvate kinase (PK) Protein, pyruvate kinase Protein, pyruvate kinase M1/2 S homeolog Protein, pyruvate kinase M1/2b Protein, PKM Protein, Pkm Protein, PyK Protein, pkma Protein, pkm Protein, LOC710798 Protein, pyk Protein, pk Protein, LOC100534543 Protein, pkm.S Protein, pkmb Protein
    Hintergrund
    Pyruvate kinase PKM is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. The pyruvate kinase isoenzyme type M2(PKM2) is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells. As a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation and Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
    Synonyms: Cytosolic thyroid hormone-binding protein,Opa-interacting protein 3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,Tumor M2-PK,p58,CTHBP,OIP3,PK2,PK3,TCB,THBP1
    Molekulargewicht
    60.1 kDa
    UniProt
    P14618
    Pathways
    Warburg Effekt
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