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PKM Produkte

(Pyruvate Kinase M1/2 (PKM))
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].

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Ausgewählte PKM Kategorien

PKM Antikörper

High quality antibodies with extensive validation data.

PKM ELISA Kits

Reliable ELISA kits for a wide range of species.

PKM Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PKM Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB, IHC, IF, IP, FACS
Validierungen
  • (9)
Kat. Nr. ABIN7166916
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB, IHC, IF, IP, FACS
Validierungen
  • (5)
Kat. Nr. ABIN7127769
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (5)
Kat. Nr. ABIN7269778
Menge 100 μL
Datenblatt Datenblatt

Empfohlene PKM ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6962948
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6969806
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6962762
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PKM Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3093387
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3134427
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN2115484
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PKM Produkten

Xie, Huang, Tang, Ye, Yang, Guo, Tian, Xie, Peng, Xie: "Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44/PKM2/AMPK Signaling." in: Current cancer drug targets, Vol. 18, Issue 6, pp. 592-599, (2018) (PubMed).

Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).

Wang, Jiang, Ji, Cai, Chen, Yu, Zhu, Zhang: "PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer." in: Scientific reports, Vol. 7, Issue 1, pp. 2886, (2018) (PubMed).

Zou, Wang, Hu, Zheng, Xu, Li: "Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317695962, (2017) (PubMed).

Gao, Wang, Yang, Chen, Jie, Li, Zhang, Liu: "Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals." in: The Journal of biological chemistry, Vol. 288, Issue 22, pp. 15971-9, (2013) (PubMed).

Parnell, Foulks, Nix, Clifford, Bullough, Luo, Senina, Vollmer, Liu, McCarthy, Xu, Saunders, Liu, Pearce, Wright, OReilly, McCullar, Ho, Kanner: "Pharmacologic activation of PKM2 slows lung tumor xenograft growth." in: Molecular cancer therapeutics, Vol. 12, Issue 8, pp. 1453-60, (2013) (PubMed).

Popescu, Cheng: "Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2." in: Somatic cell and molecular genetics, Vol. 16, Issue 6, pp. 593-8, (1991) (PubMed).

Synonyme und alternative Namen zu PKM

pyruvate kinase M1/2 (PKM), pyruvate kinase, muscle (Pkm), Pyruvate kinase (PyK), pyruvate kinase M1/2a (pkma), pyruvate kinase, muscle (pkm), pyruvate kinase, muscle (PKM), pyruvate kinase PKM (LOC710798), pyruvate kinase (PK) (pyk), pyruvate kinase PKM (pk), pyruvate kinase (pk), pyruvate kinase PKM (LOC100534543), pyruvate kinase M1/2 S homeolog (pkm.S), pyruvate kinase M1/2 (Pkm), pyruvate kinase M1/2b (pkmb), AA414905, AL024370, AL024424, cb1029, CG7070, CTHBP, Dmel\\CG7070, fj33f03, MGC53388, OIP3, Pk-2, Pk-3, PK-S, PK3, Pk3, pk3, PKM, PKM2, Pkm2, pkm2, pkm2a, pkm2b, PKM12, PYK, Pyk, TCB, THBP1, wu:fj33f03, zgc:92037

Bezeichner auf Proteinebene für PKM

  • OIP-3
  • OPA-interacting protein 3
  • PK, muscle type
  • cytosolic thyroid hormone-binding protein
  • p58
  • pyruvate kinase 2/3
  • pyruvate kinase PKM
  • pyruvate kinase isozymes M1/M2
  • pyruvate kinase muscle isozyme
  • thyroid hormone-binding protein 1
  • thyroid hormone-binding protein, cytosolic
  • tumor M2-PK
  • pyruvate kinase 3
  • CG7070-PA
  • CG7070-PB
  • PyK-PA
  • PyK-PB
  • pyruvate kinase
  • pyruvate kinase, muscle
  • pyruvate kinase M
  • ATP:pyruvate 2-o-phosphotransferase
  • Pyruvate kinase isozymes M1/M2
  • Pyruvate kinase muscle isozyme
  • CTHBP
  • cytosolic thyroid hormone binding protein/pyruvate kinase type M2
  • Pyruvate kinase PKM
  • pyruvate kinase, muscle, b
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