CCL3 Protein (AA 23-92)
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- Target Alle CCL3 Proteine anzeigen
- CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 23-92
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Produktmerkmale
- ED50 < 80 ng/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL3, corresponding to a specific activity of > 1.25x10^4 units/mg.
- Reinheit
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product CCL3 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Lyophilized recombinant human MIP-1 alpha/CCL3 (rhMIP-1 alpha) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhMIP-1 alpha remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Haltbarkeit
- 6 months
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- Target
- CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))
- Andere Bezeichnung
- MIP-1alpha/CCL3 (CCL3 Produkte)
- Synonyme
- MIP-1alpha Protein, G0S19-1 Protein, LD78ALPHA Protein, MIP-1-alpha Protein, MIP1A Protein, SCYA3 Protein, MIP-1a Protein, Scya3 Protein, AI323804 Protein, LD78alpha Protein, MIP1-(a) Protein, MIP1-alpha Protein, Mip1a Protein, CCL3L1 Protein, CCL3L3 Protein, chemokine (C-C motif) ligand 3 Protein, C-C motif chemokine ligand 3 Protein, CCL3 Protein, Ccl3 Protein
- Hintergrund
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MIP-1 alpha/CCL3, also known as LD78 alpha, is an inflammatory chemokine. MIP-1alpha belongs to the CCL chemokine family, and shares 68 % homology with MIP-1beta. The mature form of MIP-1alpha contains 69 amino acids, exists as dimers in solution, and tends to undergo reversible aggregation. The receptors of MIP-1alpha in vivo are mainly the G-protein coupled receptors CCR1 and CCR5. Upon stimulation by endogenous and exogenous agents such as Interleukin-1beta, Interferon-gamma, and lipoteichoic acid from Gram-positive bacteria, monocytes are able to secrete significant amounts of MIP-1alpha. MIP-1alpha augments the adhesions of T lymphocytes, monocytes, and neutrophils to vascular cell adhesion molecule 1. In addition, in wounds, MIP-1alpha chemo-attracts macrophages in order to accelerate the tissue repair process.Recombinant human MIP-1 alpha/CCL3 (rhMIP-1 alpha) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMIP-1 alpha has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: Macrophage Inflammatory Protein-1 alpha, CCL3, LD78 alpha - Molekulargewicht
- 7.8 kDa, observed by reducing SDS-PAGE.
- UniProt
- P10147
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Autophagie
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