IL-13 Protein (AA 22-131) (His tag)

Produktnummer ABIN1691702

Produktdetails

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-131

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses IL-13 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Interleukin-13/IL-13 (Pro22-Phe131,C-6His)

Sequenz: PVPRSVSLPL TLKELIEELS NITQDQTPLC NGSMVWSVDL AAGGFCVALD SLTNISNCNA IYRTQRILHG LCNRKAPTTV SSLPDTKIEV AHFITKLLSY TKQLFRHGPF VDHHHHHH

Produktmerkmale:

Recombinant Mouse Interleukin-13/IL-13 (Pro22-Phe131,C-6His)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Andere Bezeichnung: Interleukin-13/IL-13 (IL13 Produkte)

Synonyme: IL13 Protein, IL-13 Protein, P600 Protein, Il-13 Protein, L13 Protein, interleukin 13 Protein, IL13 Protein, Il13 Protein

Hintergrund: Recombinant Mouse Interleukin-13/IL-13 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Pro22-Phe131) of Mouse IL-13 fused with a polyhistidine tag at the C-terminus.
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58 % sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.

Molekulargewicht: 13.1 kDa

UniProt: P20109

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport