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IL-13 Protein (AA 19-132)

IL13 Spezies: Human Wirt: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Produktnummer ABIN2018016
  • Target Alle IL-13 (IL13) Proteine anzeigen
    IL-13 (IL13) (Interleukin 13 (IL13))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 19-132
    Spezies
    • 26
    • 16
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 31
    • 16
    • 8
    • 7
    • 2
    • 1
    • 1
    CHO Cells
    Produktmerkmale
    ED50 < 15 ng/mL, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 6.7x10^5 units/mg.
    Reinheit
    > 95 % as analyzed by SDS-PAGE.
    Endotoxin-Niveau
    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Lyophilized recombinant human Interleukin 13 (IL-13) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-13 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Haltbarkeit
    6 months
  • Target
    IL-13 (IL13) (Interleukin 13 (IL13))
    Andere Bezeichnung
    Interleukin 13 (IL-13) (IL13 Produkte)
    Synonyme
    IL13 Protein, IL-13 Protein, P600 Protein, Il-13 Protein, L13 Protein, interleukin 13 Protein, IL13 Protein, Il13 Protein
    Hintergrund
    Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and mouse IL-13 is cross-species reactive.Recombinant human interleukin 13 expressed in CHO cells is glycosylated protein with molecular weight range from 25 to 45 kDa shown in non-reducing SDS-PAGE.
    Synonyms: NC30 (Human), P600 (Murine),IL-13 (human)
    Molekulargewicht
    25-45 kDa, observed by non-reducing SDS-PAGE.
    UniProt
    P35225
    Pathways
    JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
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