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Flagellin Protein (FliC)

FliC Spezies: Human, Maus Wirt: Salmonella typhimurium >95 % (SDS-PAGE) SDS Active
Produktnummer ABIN1344457
  • Target Alle Flagellin (FliC) Proteine anzeigen
    Flagellin (FliC)
    Biologische Aktivität
    Active
    Spezies
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Quelle
    • 7
    • 5
    • 1
    Salmonella typhimurium
    Applikation
    SDS-PAGE (SDS)
    Spezifität
    Binds to human and mouse TLR5 (Toll-like receptor 5).
    Kreuzreaktivität
    Human, Maus
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product FliC Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin (high Purity) at a concentration of 5-50ng /ml and in vivo at a starting concentration of 0.1-1μg /mouse.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute with 100 μL sterile water.
    Konzentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Haltbarkeit
    6 months
  • Target
    Flagellin (FliC)
    Andere Bezeichnung
    Flagellin (FliC Produkte)
    Synonyme
    hag Protein, flaG Protein, flagellin Protein, flagellin (flic) Protein, flagellin E Protein, flagellin protein flic Protein, fliC Protein, FliC Protein, fliC+F2048 Protein, CJJ81176_1339 Protein, C8J_1256 Protein
    Hintergrund
    Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
    UniProt
    P06179
    Pathways
    Inflammasome
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