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Flagellin Protein (FliC) (Mutant) (His tag)

FliC Spezies: Human, Maus Wirt: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE)
Produktnummer ABIN6253486
  • Target Alle Flagellin (FliC) Proteine anzeigen
    Flagellin (FliC)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Mutant
    Spezies
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Quelle
    • 7
    • 4
    • 2
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses Flagellin Protein ist gelabelt mit His tag.
    Verwendungszweck
    Flagellin (TLR5 Mutant) (rec.)
    Spezifität
    The native flagellin [FliC] from Salmonella enterica Serovar Typhimurium strain ATCC14028 (aa 1-495) contains a substitution of amino acids 90-97 required for TLR5 signaling by a motif from a non-signaling flagellin and is fused at the N-terminus to a His-tag.
    Produktmerkmale
    Protein. The native flagellin [FliC] from Salmonella enterica Serovar Typhimurium strain ATCC14028 (aa 1-495) contains a substitution of amino acids 90-97 required for TLR5 signaling by a motif from a non-signaling flagellin and is fused at the N-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.01EU/μg purified protein (LAL test, Lonza). Lyophilized. Contains PBS. Not detected by human and mouse TLR5 (Toll-like receptor 5). Purity: >95 % (SDS-PAGE). Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) or the intracellular NLRC4 protein. The Flagellin (TLR5 Mutant) (rec.) cannot be detected by human and mouse TLR5. It has not been tested on NLRC4.
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.01EU/μg purified protein (LAL test, Lonza).
    Biological Activity Comment
    Does not activate TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, in vivo on expression of CCL20 or IL-6. It can be used as negative control for TLR5 signaling assays.
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    Discover our top product FliC Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Konzentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Handhabung
    After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.

  • Target
    Flagellin (FliC)
    Andere Bezeichnung
    Flagellin (FliC Produkte)
    Synonyme
    hag Protein, flaG Protein, flagellin Protein, flagellin (flic) Protein, flagellin E Protein, flagellin protein flic Protein, fliC Protein, FliC Protein, fliC+F2048 Protein, CJJ81176_1339 Protein, C8J_1256 Protein
    Hintergrund

    Alternate Names/Synonyms: FliC (TLR5 Mutant)

    Product Description: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) or the intracellular NLRC4 protein. The Flagellin (TLR5 Mutant) (rec.) cannot be detected by human and mouse TLR5. It has not been tested on NLRC4.

    Pathways
    Inflammasome
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