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Chicken Polyclonal GCG Primary Antibody für IEM, ICC - ABIN617889
Pak, Cha, Rajotte, McArthur, Yoon: Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody. in Diabetologia 1991
Show all 48 Pubmed References
Human Monoclonal GCG Primary Antibody für IHC (p) - ABIN3043073
Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct. in Lymphology 2011
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Human Polyclonal GCG Primary Antibody für IHC (p) - ABIN3042419
Chen, Yang, Zheng, Hu, Kong, Zhang: Effect of catch-up growth after food restriction on the entero-insular axis in rats. in Nutrition & metabolism 2010
Show all 6 Pubmed References
Human Monoclonal GCG Primary Antibody für CyTOF, FACS - ABIN4900763
Kornete, Beauchemin, Polychronakos, Piccirillo: Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. in Autoimmunity 2013
Show all 3 Pubmed References
Human Polyclonal GCG Primary Antibody für ELISA, IF - ABIN2473808
Koistinaho, Hatanpää, Hervonen: Human paraganglion cells differentiate into adrenergic neurons in culture. in Experimental neurology 1990
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Human Monoclonal GCG Primary Antibody für ELISA, WB - ABIN966191
Geliebter, Hashim, Gluck: Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED). in Physiology & behavior 2008
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Human Polyclonal GCG Primary Antibody für ELISA - ABIN2473805
Woods, Lutz, Geary, Langhans: Pancreatic signals controlling food intake; insulin, glucagon and amylin. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006
Human Polyclonal GCG Primary Antibody für IF (p), IHC (p) - ABIN704246
Sun, Nie, Wang, Yang, Meng, Xiao, Xiang, Li, Fu, Wang: Factors that Affect Pancreatic Islet Cell Autophagy in Adult Rats: Evaluation of a Calorie-Restricted Diet and a High-Fat Diet. in PLoS ONE 2016
Human Monoclonal GCG Primary Antibody für ELISA, WB - ABIN969171
Arnés, González, Tornero-Esteban, Sancho, Acitores, Valverde, Delgado, Villanueva-Peñacarrillo: Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle. in International journal of molecular medicine 2008
Human Polyclonal GCG Primary Antibody für RIA - ABIN2473807
Figueroa, Hess, Ky, Brown, Sandig, Hermanowski-Vosatka, Twells, Todd, Austin: Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000
RYGB increased circulating bile acids, ileal Takeda G protein-coupled receptor 5 (zeige XCR1 Antikörper) (TGR5 (zeige GPBAR1 Antikörper)) and mTORC1 signaling activity, as well as GLP-1 production in both mice and human subjects. Inhibition of ileal mTORC1 signaling by rapamycin significantly attenuated the stimulation of bile acid secretion, TGR5 (zeige GPBAR1 Antikörper) expression and GLP-1 synthesis induced by RYGB in lean and diet-induced obese mice.
Glucagon role in the pathophysiology of type 2 diabetes.[review]
This review summarizes the current knowledge regarding the role of GLP-1 in the protection against oxidative damage and the activation of the Nrf2 (zeige GABPA Antikörper) signaling pathway. [review]
Study concludes that in healthy subjects, glucagon-like peptide-1 (GLP-1) increases cardiac output acutely due to a GLP-1-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.
Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.
The results demonstrate that glucagon-like peptide-1 and insulin (zeige INS Antikörper) synergistically and additively activate vagal afferent neurons.
DPP-4 (zeige DPP4 Antikörper) activity and GLP (zeige RCBTB1 Antikörper)-1total levels were higher in patients with microvascular complications associated with T2DM. Contrary to expectations, no negative correlation was seen between GLP-1 and DDP (zeige TIMM8A Antikörper)-4 levels. This result suggests the possible inefficacy of DDP (zeige TIMM8A Antikörper)-4 activity as a marker to predict in vivo degradation of endogenous GLP-1.
Data suggest that cAMP acts as amplifier of insulin (zeige INS Antikörper) secretion triggered by Ca2 (zeige CA2 Antikörper)+ elevation in beta-cells; both messengers are also positive modulators of glucagon release from alpha-cells, but in this case cAMP signaling may be the important regulator and Ca2 (zeige CA2 Antikörper)+ signaling has a more permissive role. [REVIEW]
This study provides evidence that, in HepG2 cells, GLP-1 may affect cholesterol homeostasis by regulating the expression of miR (zeige MLXIP Antikörper)-758 and ABCA1 (zeige ABCA1 Antikörper).
This study reports the transition dipole strengths and frequencies of the amyloid beta-sheet amide I mode for the aggregated proteins amyloid-beta1-40, calcitonin (zeige CALCA Antikörper), alpha-synuclein, and glucagon.
data show that the CREB (zeige CREB1 Antikörper)/CRTC2 (zeige CRTC2 Antikörper)-dependent transcriptional pathway is critical for regulating glucose homeostasis by controlling production of GLP-1 from the L cells at the level of transcription, maturation, and exocytosis.
the results of the present study indicated that GLP1 may be a promising target for the development of novel therapeutic strategies for HGinduced nephropathy, and may function through the activation of SIRT1 (zeige SIRT1 Antikörper)
this study, we investigated whether glucagon and glucagon-like peptide-1 (GLP-1), hormones produced by alpha cells, contribute to insulin (zeige INS Antikörper) secretion in INS-1 cells, a beta (zeige SUCLA2 Antikörper) cell line. Co-treatment with glucagon and exendin-4 (Ex-4), a GLP-1 receptor (zeige GLP1R Antikörper) agonist, additively increased glucose-stimulated insulin (zeige INS Antikörper) secretion in INS-1 cells
FXR (zeige NR1H4 Antikörper) exerts its function in L cells through interacting with CREB (zeige CREB1 Antikörper), a crucial transcriptional regulator of cAMP-CREB (zeige CREB1 Antikörper) signaling pathway, to inhibit its transcriptional activity. Targeting FXR (zeige NR1H4 Antikörper) to rescue GLP-1 secretion may be a promising strategy for type II diabetes.
results show that glucagon controls gene expression and metabolic zonation in the liver through a counterplay with the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway.
Data (including data from studies using transgenic and knockout mice) suggest that Glp1/Glp1r (zeige GLP1R Antikörper) signaling in insulin (zeige INS Antikörper)-secreting cells plays important role in development of glucose intolerance in obesity; however, Glp1r (zeige GLP1R Antikörper) is not required in insulin (zeige INS Antikörper)-secreting cells for improvement in glucose intolerance after weight loss due to bariatric surgery (here, vertical sleeve gastrectomy).
Chronic stress accelerates DPP4-mediated GLP-1 degradation and alters plasma adiponectin, accelerating vascular senescence and impairing ischemia-induced neovascularization.
Data suggest that metabolism of glutamine (zeige GFPT1 Antikörper) and related analogs by Gdh (zeige UGDH Antikörper) in intestinal L-cells explains why Glp1 secretion, but not that of insulin (zeige INS Antikörper) by pancreatic beta-cells, is activated by these secretagogues. (Gdh (zeige UGDH Antikörper) = glutamate (zeige GRIN1 Antikörper) dehydrogenase; Glp1 = glucagon-like peptide 1)
Glucokinase (zeige GCK Antikörper) governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 (zeige FFAR1 Antikörper) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor (zeige GLP2R Antikörper) mRNA primarily in small intestinal and colon tissues and increased nutrient intake increases ileal proglucagon mRNA and plasma glucagon-like peptide 2
Data suggest that casein, safflower oil, sucrose, and sweetening agent rebaudioside A stimulate GLP1 release/secretion from enteroendocrine cells. (GLP1 = glucagon-like peptide 1, a peptide fragment derived from proglucagon)
The patterns of colocalization of the K cell marker, glucagon-like insulinotropic peptide, and L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated.
The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I
, glucagon-like peptide-1
, preproglucagon B
, glucagon preproprotein
, preproglucagon A
, glucagon I
, proglucagon I