Protein Arginine Methyltransferase 2 (PRMT2) Peptid
PRMT2
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
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- Target Alle PRMT2 Produkte
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-PRMT2 antibody (Catalog #: ARP40196_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Synonyme
- PRMT2 Peptide, DKFZp459N1919 Peptide, HRMT1L1 Peptide, Hrmt1l1 Peptide, AI504737 Peptide, protein arginine methyltransferase 2 Peptide, protein arginine methyltransferase 2 L homeolog Peptide, protein arginine N-methyltransferase 2 Peptide, PRMT2 Peptide, Prmt2 Peptide, prmt2.L Peptide
- Hintergrund
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The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Alias Symbols: HRMT1L1
Protein Interaction Partner: ESR1,ESR2,NCOA1,NCOA6,PGR,PPARG,PRMT2,RARA,RXRA,THRB,BAT2,CPSF7,DMRTB1,ESR1,ESR2,HNRNPUL1,NCOA1,NCOA6,PGR,PRMT2,RB1,RXRA,THRB,BAT2,CPSF7,DMRTB1,ESR1,HNRNPUL1
Protein Size: 433 - Molekulargewicht
- 48 kDa
- Gen-ID
- 3275
- NCBI Accession
- NM_001535, NP_001526
- UniProt
- P55345
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