A synthetic peptide for use as a blocking control in assays to test for specificity of PRMT2 antibody, Alternative Names: PRMT2 control peptide, PRMT2 antibody Blocking Peptide, Anti-PRMT2 Blocking Peptide, Protein Arginine Methyltransferase 2 Blocking Peptide, PRMT2, PRMT-2, PRMT 2, PRMT-2 Blocking Peptide, PRMT 2 Blocking Peptide
PRMT2 Peptide, DKFZp459N1919 Peptide, HRMT1L1 Peptide, Hrmt1l1 Peptide, AI504737 Peptide, protein arginine methyltransferase 2 Peptide, protein arginine methyltransferase 2 L homeolog Peptide, protein arginine N-methyltransferase 2 Peptide, PRMT2 Peptide, Prmt2 Peptide, prmt2.L Peptide
Hintergrund
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.