Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-PRMT2 antibody (Catalog #: ARP40195_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
PRMT2 Peptide, DKFZp459N1919 Peptide, HRMT1L1 Peptide, Hrmt1l1 Peptide, AI504737 Peptide, protein arginine methyltransferase 2 Peptide, protein arginine methyltransferase 2 L homeolog Peptide, protein arginine N-methyltransferase 2 Peptide, PRMT2 Peptide, Prmt2 Peptide, prmt2.L Peptide
Hintergrund
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Alias Symbols: HRMT1L1, MGC111373
Protein Interaction Partner: ESR1,ESR2,NCOA1,NCOA6,PGR,PPARG,PRMT2,RARA,RXRA,THRB,BAT2,CPSF7,DMRTB1,ESR1,ESR2,HNRNPUL1,NCOA1,NCOA6,PGR,PRMT2,RB1,RXRA,THRB,BAT2,CPSF7,DMRTB1,ESR1,HNRNPUL1