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PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes.
FAM20C (zeige FAM20C Proteine) plays a role in 7B2 (zeige SCG5 Proteine)-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 (zeige SCG5 Proteine) function is regulated by alternative splicing.
in the processing of hypothalamic neuropeptides in huntington disease (zeige HTT Proteine) may partially arise from decreased PC1/3 (zeige PCSK1 Proteine) and PC2 (zeige KRT6B Proteine) expressions.
variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin (zeige INS Proteine) secretion, but also with lower glucagon (zeige GCG Proteine) levels, which could potentially counteract the effects of decreased insulin (zeige INS Proteine) secretion on the risk of type 2 diabetes
The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population
differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH (zeige POMC Proteine) syndrome than in Cushing disease of proprotein convertase-2
PC1/3 (zeige PCSK1 Proteine) governs the endocrine, and PC2 (zeige KRT6B Proteine) the neuronal processing, of proCCK, whereas PC5 (zeige PCSK5 Proteine)/6 contributes only to a modest endocrine synthesis of CCK-22 (zeige CCK Proteine).
SEMA3F (zeige SEMA3F Proteine), CLEC16A, LAMA3 (zeige LAMA3 Proteine), and PCSK2 variants have roles in myocardial infarction in Japanese individuals
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin (zeige GHRL Proteine).
prominently expressed in PTHrP-expressing human cancer cell lines originating from tumors of the breast, lung, prostate, as well as lymphoma
Prohormone convertase PC2 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.
Pcsk2 has been sequenced and characterized.
Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 (zeige PCSK1 Proteine) and proprotein convertase 2 mutant mouse spinal cords.
Study reports that PC2 (zeige CBX4 Proteine) null mice had increased number of mu opioid receptors in different brain areas. These mice also exhibited enhanced morphine-induced antinociception but reduced tolerance to and dependence on morphine.
PC1 (zeige PCSK1 Proteine) and PC2 (zeige CBX4 Proteine) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (zeige TAC1 Proteine) protein
activation of the hypothalamic GPR40 (zeige FFAR1 Proteine)/FFA1 signaling pathway may regulate beta-endorphin (zeige POMC Proteine) release via PC2 (zeige CBX4 Proteine), and regulate the endogenous pain control system
Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 (zeige IGF1 Proteine) and female sexual maturation, it also might be involved in the regulation of aging.
Islets of Langerhans from prohormone convertase-2 knockout mice show alpha-cell hyperplasia and tumorigenesis with elevated alpha-cell neogenesis.
Pc2 (zeige CBX4 Proteine) activity can be downregulated by mutant PAX6 (zeige PAX6 Proteine).
PC2 (zeige CBX4 Proteine) alone is responsible for catalyzing the conversion of pFE (zeige PTH1R Proteine)(22) to pFQ(7) and pSE(14), all peptides implicated in regulation of suckling-induced prolactin (zeige PRL Proteine) release.
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 (zeige SCG5 Proteine) protein has a preferential effect on glucagon (zeige GCG Proteine) synthesis
PCSK2 is needed for normal food intake and processing
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
KEX2-like endoprotease 2
, neuroendocrine convertase 2
, prohormone convertase 2
, NEC 2
, proprotein convertase 2
, proprotein convertase subtilisin/kexin type 2
, proprotein convertase type 2
, convertase PC2
, proprotein convertase subtilisin/kexin type 2 L homeolog
, prohormone convertase2