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PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes.
FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing.
in the processing of hypothalamic neuropeptides in huntington disease may partially arise from decreased PC1/3 and PC2 expressions.
variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin secretion, but also with lower glucagon levels, which could potentially counteract the effects of decreased insulin secretion on the risk of type 2 diabetes
The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population
differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH syndrome than in Cushing disease of proprotein convertase-2
PC1/3 governs the endocrine, and PC2 the neuronal processing, of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22.
SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin.
prominently expressed in PTHrP-expressing human cancer cell lines originating from tumors of the breast, lung, prostate, as well as lymphoma
A marked decrease in the ratio of the PC2 precursor to the total enzymatic pool is observed in the frontal cortex of Alzheimer patients; however, the content and enzymatic activity of the PC2 mature form are similar in Alzheimer patients and controls.
concluded that there are two novel TRE-like sequences in the hPC2 promoter and that these regions act in concert in a unique manner to facilitate the effects of thyroid hormone and 9-cis-retinoic acid on PC2
PC1 and PC2 in are abnormally expressed and processed in human colorectal liver metastases
Single nucleotide polymorphisms in PCSK2 is associated with type 2 diabetes
PC1 and PC2 were primarily expressed in neurons, whereas PACE4 appeared to be largely restricted to glia. Thus, elevated PACE4 may modulate the bioactivity of proteins secreted in the ONH and retina.
Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease.
Prohormone convertase PC2 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.
Pcsk2 has been sequenced and characterized.
Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 and proprotein convertase 2 mutant mouse spinal cords.
Study reports that PC2 null mice had increased number of mu opioid receptors in different brain areas. These mice also exhibited enhanced morphine-induced antinociception but reduced tolerance to and dependence on morphine.
PC1 and PC2 are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 protein
activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin release via PC2, and regulate the endogenous pain control system
Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 and female sexual maturation, it also might be involved in the regulation of aging.
Islets of Langerhans from prohormone convertase-2 knockout mice show alpha-cell hyperplasia and tumorigenesis with elevated alpha-cell neogenesis.
Pc2 activity can be downregulated by mutant PAX6.
PC2 alone is responsible for catalyzing the conversion of pFE(22) to pFQ(7) and pSE(14), all peptides implicated in regulation of suckling-induced prolactin release.
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein has a preferential effect on glucagon synthesis
PCSK2 is needed for normal food intake and processing
These results demonstrate a prominent role for cathepsin L, jointly with PC1/3 and PC2, for production of dynorphins in brain.
PC2 has a role in endoproteolytic processing in mouse brain
Processing of pro-CART revealed that PC2 is more potent than PC1/3 in generating bioactive CART I; bioactive CART II is solely generated by PC2; and PC1/3 is predominantly active in liberating the two intermediate CART fragments, 33-102 and 10-89.
alpha-melanocyte-stimulating hormone was not detected in brain and pituitary glands of prohormone convertase 2 - deficient mice
hormones processed by PC2 affected processes that regulate islet cell differentiation and maturation in embryos and adults.
data indicate that null prohormone convertase 2 and 7B2 protein are not phenotypically equivalent in pituitary proopiomelanocortin (POMC) biosynthesis and granule content
In the absence of PC1/3, PC2 can initiate complete processing of proIAPP to IAPP by cleaving the precursor at either its NH(2)- or COOH-terminal cleavage sites.
prohormone convertase (PC)2 in cerebral neurons, compared to PC1, which governs the processing of procholecystokinin in intestinal endocrine cells.
evidence for PC2 as the major convertase in alpha-cells leading to mature glucagon production
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
KEX2-like endoprotease 2
, neuroendocrine convertase 2
, prohormone convertase 2
, NEC 2
, proprotein convertase 2
, proprotein convertase subtilisin/kexin type 2
, proprotein convertase type 2
, convertase PC2
, proprotein convertase subtilisin/kexin type 2 L homeolog
, prohormone convertase2