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maspin is a powerful context-dependent tumor suppressor.
these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR (zeige EGFR Proteine) ligands, but EGF (zeige EGF Proteine) appears to be the only able to induce SerpinB5 nuclear localization.
perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression
evidence demonstrates that D(346) is a critical cis (zeige CISH Proteine)-element in maspin sequence that determines the molecular context and subcellular localization of maspin.
a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth.
results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation
The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo.
SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma
PAR-1 (zeige MARK2 Proteine) negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype
Results describe a mechanism by which maspin exerts its effect on endothelial cell adhesion and migration through an integrin signal transduction pathway.
SERPINB5 may play an important role in rectal cancer progression and response to neoadjuvant CCRT and serve as a novel prognostic factor.
maspin expression has a prognostic role in breast cancer. Maspin expression is related to increased angiogenesis. Subcellular localization of maspin can strongly affect cancer prognosis. Cytoplasmic maspin relates to poor prognostic parameters whereas nuclear maspin relates to good prognostic ones.
Maspin nuclear expression in colorectal carcinoma buds may be helpful for a proper budding assessment and may serve as a negative prognostic factor.
The expression of maspin in the cytoplasm alone could be useful for predicting unfavorable prognoses in patients with p-stage IA lung adenocarcinoma
The severity of hip OA can be related to angiogenesis pathways that are not maspin-mediated.
SNPs affected SERPINB5 expression and protein stability, which significantly correlated with tumour expression and subsequently with tumour development and aggressiveness. Taken together, our findings regarding these biomarkers provide a prediction model for risk assessment.
Maspin is spontaneously secreted as an exosomal protein to regulate tumor/stromal interactions.
Study results provide new insights into the molecular mechanisms of maspin suppression in response to HBx, and revealed nuclear IKKalpha (zeige CHUK Proteine) as a prognostic biomarker and a potential therapeutic target to improve the clinical outcome of HBV-associated HCC (zeige FAM126A Proteine) patients.
Mechanistic investigations found that quercetin suppressed Snail (zeige SNAI1 Proteine)-dependent Akt (zeige AKT1 Proteine) activation by upregulating maspin and Snail (zeige SNAI1 Proteine)-independent a disintegrin and metalloproteinase (ADAM) 9 (zeige ADAM9 Proteine) expression pathways to modulate the invasive ability of NSCLC cells.
High HDAC1 (zeige HDAC1 Proteine) expression may contribute to the aggressiveness of human breast cancer with cytoplasmic-only expression of maspin
may act as a tumor suppressor
peptidase inhibitor 5
, protease inhibitor 5
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
, serine (or cysteine) proteinase inhibitor, clade B, member 5
, serine protease inhibitor 7
, serpin B5
, protease inhibitor 5 (maspin)
, serine (or cysteine) peptidase inhibitor, clade B, member 5