SERPINB5 Protein (AA 1-375, Ser176Pro-Mutant, Val66Ile-Mutant, Val187Leu-Mutant)

Produktnummer ABIN2018223

Produktdetails

Target: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-375, Val66Ile-Mutant, Ser176Pro-Mutant, Val187Leu-Mutant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE and HPLC analysis.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human Maspin (rhMaspin) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhMaspin remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Andere Bezeichnung: Maspin (SERPINB5 Produkte)

Synonyme: 1110036M19Rik Protein, AI462524 Protein, AI646751 Protein, Maspin Protein, PI-5 Protein, Spi7 Protein, ovalbumin Protein, PI5 Protein, maspin Protein, Pi5 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 5 Protein, serpin family B member 5 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog Protein, Serpinb5 Protein, SERPINB5 Protein, serpinb5.S Protein

Hintergrund: Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).Recombinant human Maspin (rhMaspin) produced in E. coli is a single non-glycosylated polypeptide chain containing 375 amino acids. rhMaspin has a molecular mass of 42.1 kDa analyzed by reducing SDS-PAGE.
Synonyms: Serpin B5, PI-5

Molekulargewicht: 42.1 kDa, observed by reducing SDS-PAGE.

UniProt: P36952

Pathways: p53 Signalweg