Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR (zeige CYP27B1 Proteine) inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe (zeige APOE Proteine)(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut (zeige GUSB Proteine) inflammation.
Vdr (zeige CYP27B1 Proteine) and Casr (zeige CASR Proteine) are required for beta-catenin (zeige CTNNB1 Proteine)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
Absence of VDR-mediated PPARgamma suppression underlies alopecia in VDR-/- mice.
Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.
genetic association study in population in Italy: Data suggest that an SNP in VDR (rs2228570, C>T) is not associated with type 2 diabetes (T2D); study involved 883 adult subjects with T2D and 830 adult control subjects. [REVIEW of one genetic association study]
variation within the VDR gene may affect the immune response against T. cruzi, increasing the probability of cardiac complications in infected individuals
IGFBP-3 (zeige IGFBP3 Proteine) Interacts with the Vitamin D Receptor in Insulin (zeige INS Proteine) Signaling Associated with Obesity in Visceral Adipose Tissue
RFC, IL15 and VDR germline variants are associated with minimal residual disease in pediatric B-cell precursor ALL
The VDR BsmI variant was associated with hypertriglyceridemia and may be predisposed to developing metabolic syndrome.
colorectal cancer (CRC (zeige CALR Proteine)) patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 (zeige CYP24A1 Proteine) and CYP27B1 (zeige CYP27B1 Proteine). Polymorphic genotypes cause a lower correlation between the forms of vitamin D.
This study found that the Bsm VDR variant influences bone density among lead workers.
Haplotypes (TG) of rs11168266-rs11168267 in the VDR gene confers susceptibility to ankylosing spondylitis in Han Chinese population.
The FokI polymorphism in the VDR gene may contribute to susceptibility to systemic lupus erythematosus in Egyptian children and adolescents.
VDR protein levels were reduced in a majority of keloid scars. Further, the percentage of epidermal cells displaying nuclear VDR localization was significantly lower in keloid scars compared with normal skin samples. Interestingly, analysis of VDR-positive nuclei among different normal skin samples showed a significant reduction in nuclear localization in epidermis of black donors compared with white donors.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (zeige NOS2 Proteine)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (zeige NOS2 Proteine) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein