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Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
While further studies are required to determine the mechanisms, by which vitamin D activity regulates osteoclastic bone resorption, our findings suggest that VDR-mediated activity in mature osteoclasts is required to moderate osteoclastic activity during growth and in ovariectomy-induced bone loss.
Our data indicate abnormal osteoclastogenesis due to the absence of Vdr expression, consistent with direct effects of vitamin D signalling being important for regulating the maturation and resorptive activities of osteoclasts.
We conclude that the relative VDR level and the 1,25D availability to cells, are important co-determinants for whether 1,25D plays a promoting or suppressive role in osteoblast-mediated osteogenic activity.
Taken together, our in vivo studies using ChIP-seq analyses and the mini-gene transgenic mice improve our understanding of the tissue-specific regulatory mechanisms of controlling VDR expression and the mechanisms of action of the VDR.
Low VDR expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
These findings suggest that Vdr has a cell-intrinsic function in early erythroid progenitors.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut inflammation.
Unique protective roles for vitamin D signaling during colitis in the colon epithelium as well as nonepithelial cells in the colon microenvironment (i.e., modulation of M biology).
Vdr and Casr are required for beta-catenin-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
FokI rs2228570 polymorphism is not associated with cow's milk protein allergy.
there is no evidence of an association between FokI polymorphism and Intervertebral Disc Degeneration in the general population; ethnic predisposition has been shown (Systematic Review)
Nested case-control correlative study revealed that vitamin D levels were not significantly associated with development of aromatase inhibitor-induced arthralgia (AIA) during breast cancer treatment, however, patients with the Fok-I VDR variant genotype were more likely to have a significant reduction in IL-1beta level, and less likely to develop AIA.
Studied link of Vitamin D Receptor (VDR) genetic polymorphisms with cervical spondylotic myelopathy (CSM); found the VDR-FokI polymorphism to be closely associated with the susceptibility to CSM.
vitamin D receptor gene polymorphisms and prostate cancer: there were no differences between the prostate cancer group and the control group
CTA-018 induced VDR expression (15-fold lower than 1alpha,25(OH)2D3) and is under phase II clinical trial, whereas CTA-091 was not able to efficiently induce the VDR expression (>2000 nM). To explore the molecular mechanism, binding specificity of these two vitamin D analogues along with native ligand was extensively studied through in silico approaches
improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.
in human gingival fibroblasts and human periodontal ligament cells, the FF-VDR genotype is associated with the more remarkable up-regulation of CYP24A1than the other genotypes, indicating that transcriptional activation of FF-VDR might be higher than those of other vitamin D receptors.
no significant differences in bacterial load were found in patients carrying periodontal disease susceptibility alleles of IL6, IL10 and VDR genes
The VDR FokI polymorphism was also associated with excessive daytime sleepiness (p = 0.016).
These data indicate that VDR and DC-SIGN genetic variations are related to the susceptibility of oral paracoccidioidomycosis in the group of patients analysed.
TaqI polymorphism within intron 8-exon 9 of the VDR gene is not associated with an increased risk of periodontitis in an Ethnic Tamillian population.
Study aimed to explain Cdx-2 variant association with immune-related conditions. Authors hypothesised that the effect of Cdx-2 polymorphism on VDR expression in monocytes/macrophages, devoid of the CDX-2 TF, is indirect and dependent on circulating 25(OH)D3 and VDR methylation.
According to the results obtained the rs1544410 AA genotype (VDR gene) and the presence of less than 20 CAG repeats in the 1st exon (AR gene) are the risk factors for the development of prostate cancer. The het- erozygous genotype 722 CT (XRCC3 gene) demonstrated the protective effect.
Clinical, genetic, and experimental results from this study point toward genetic variation in VDR as a novel determinant of the outcome of pancreatic cancer patients treated with chemotherapy. Results support evidence for a modulatory role of the vitamin D pathway for the survival of advanced pancreatic cancer patients.
Gene polymorphism of VDR gene are associated with the leprosy disease.
CYP24A1 (rs6013897) locus was found to interact with psychosis status in predicting total ventricular volume. Further, the VDR locus BSML (rs1544410) interacted with patient status in predicting white matter and whole brain volumes.
In this study, we have shown that HBV downregulates the expression levels of Vitamin D receptor in the HBV-infected HepG2 cell line, thereby preventing the effect of Vitamin D on viral transcription and production.
we investigated whether polymorphisms within the vitamin D receptor (VDR) ,1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) , cytochrome P450 monooxygenase 25(OH)D-1alpha-hydroxylase (CYP27B1) and GC (encoding the vitamin D binding protein (VDBP)) (1296) genes could play a role in DFX pharmacokinetics
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein