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Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma (zeige PPARG Proteine)) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR (zeige MLXIP Proteine)-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD (zeige SMAD1 Proteine) signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR (zeige CYP27B1 Proteine) inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe (zeige APOE Proteine)(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut (zeige GUSB Proteine) inflammation.
CT genotype and the C allele of VDR were significantly associated with increased risks of childhood autism spectrum disorder.
Study found a significant association between multiple sclerosis and the VDR FokI polymorphism in our region of Turkey.
VDR's Fok-I and Taq-I show significant association with risk of RRMS, while Apa-I and Bsm-I are not related to the risk of the disease in Iranian Kurds.
The VDR rs2228570 polymorphism increases the risk of ovarian cancer in Caucasian populations in a dominant genetic model.
The present study indicates an association between VDR (zeige CYP27B1 Proteine) and vitamin D binding protein (zeige GC Proteine) Single Nucleotide Polymorphisms and Type 1 Diabetes Mellitus among Turkish subjects.
Review/Meta-analysis: VDR B allele, and BB + Bb genotypes of Bsm I variant, Tt genotype of Taq I variant might be risk factors for diabetic nephropathy.
The VDR Bb genotype is an independent predictor of developing secondary hyperparathyroidism in patients with end stage kidney disease.
FokI and TaqI VDR variants are significantly associated with systemic lupus erythematosus in an eastern Indian cohort.
results suggests that there may be a relationship between certain VDR genotype combinations and the risk of preterm birth.
VDR BsmI polymorphism was associated with decreased risk of periodontitis in Chinese individuals from South China (meta-analysis).
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (zeige NOS2 Proteine)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (zeige NOS2 Proteine) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein