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Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut inflammation.
Unique protective roles for vitamin D signaling during colitis in the colon epithelium as well as nonepithelial cells in the colon microenvironment (i.e., modulation of M biology).
Vdr and Casr are required for beta-catenin-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
Absence of VDR-mediated PPARgamma suppression underlies alopecia in VDR-/- mice.
Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.
VDR is important for the maintenance of physiological level of Axin1
The data support the hypothesis that Vdr in mature adipocytes alters the metabolic response to high-fat diets and exerts anti-proliferative effects on the mammary epithelium.
The data demonstrate that deficiency in the vitamin D signaling via VDR knockout enhances the pathological phenotype in this experimental cardiomyopathy and suggest an important role for vitamin D in modulating disease severity in common cardiovascular disorders.
Absence of VDR or presence of an unliganded VDR does not affect the profile and function of ex vivo generated bone marrow-derived dendritic cells.
In this study, we have shown that HBV downregulates the expression levels of Vitamin D receptor in the HBV-infected HepG2 cell line, thereby preventing the effect of Vitamin D on viral transcription and production.
we investigated whether polymorphisms within the vitamin D receptor (VDR) ,1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) , cytochrome P450 monooxygenase 25(OH)D-1alpha-hydroxylase (CYP27B1) and GC (encoding the vitamin D binding protein (VDBP)) (1296) genes could play a role in DFX pharmacokinetics
These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study.
The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes is reviewed.
Vitamin D Receptor Gene SNPs and the environment interact to Influence survival in hemodialysis patients.
Results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of premature birth.
SNPs of the VDR and GC genes are associated with vitamin D deficiency in postmenopausal Mexican women.
VDR gene FokI polymorphism is associated with papillary thyroid cancer.
No significant associations were found between the VDR polymorphisms analysed and Developmental dysplasia of the hip . Further work need to be performed using genomewide analysis to elucidate the genetic basis of Developmental dysplasia of the hip .
There was no significant association detected between BMI and rs1544410 of VDR in the Emirati population
Apparently, VDR-mediated signaling pathways seem to be dysregulated in those pathological conditions
Vitamin D Receptorgene TaqI and BsmI polymorphisms might contribute to the increased risk of hallux valgus in Chinese population. Apal or Fokl polymorphisms showed no increased susceptibility.
PTPN2, an anti-inflammatory factor regulated by VDR, was reduced in type 2 diabetics with chronic kidney disease stages 1-2.
ApaI gene polymorphism and Fok1 FF genotype were associated with renal cell carcinoma susceptibility in Asians
findings show polymorphism Taq-1 occurring in the vitamin D receptor may have an impact on the development of acute pancreatitis due to the lack of the protective role of vitamin D.
only VDR FokI polymorphism is associated with Hashimoto's thyroiditis risk in Asian population, but not in Caucasians; and the TaqI, ApaI and BsmI polymorphisms have not positive association neither in the overall population (Meta-Analysis)
Loss of function VDR mutation is associated with Hereditary 1,25-dihydroxyvitamin D-resistant rickets.
JNK1 and VDR act as tumor suppressors, and their stromal expression levels are associated with prognosis in esophageal squamous cell carcinoma.
Associations between VDR gene polymorphisms and osteoporosis risk and bone mineral density in postmenopausal women have been documented. (Meta-analysis)
Vitamin D deficiency and vitamin D receptor variants in mothers and their neonates are risk factors for neonatal sepsis
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein