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the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein (zeige RIPK1 Proteine) kinase (zeige CDK7 Proteine) 1 (RIP1 (zeige UQCRFS1 Proteine))-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.
Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) tissues and demonstrate that RARgamma could promote HCC (zeige FAM126A Proteine) invasion and metastasis by regulating E-cadherin (zeige CDH1 Proteine) reduction.
Dual small interfering RNA (siRNA) silencing of RARalpha (zeige RARA Proteine) and RARgamma reversed RA blockade of P4-induced CK5 (zeige KRT5 Proteine). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (zeige KRT5 Proteine) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis.
A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers.
deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98 (zeige NUP98 Proteine)-RARG-mediated transformation
The current status of knowledge indicates that there might be inter- or overlapping actions between PPARg (zeige PPARG Proteine) and RARs (zeige RARS Proteine), and there might be an association of PPARg (zeige PPARG Proteine)/RARs (zeige RARS Proteine)(RARa (zeige RARA Proteine), RARb (zeige RARB Proteine), and RARg) with renal diseases
RARgamma in concert with ATRA regulates protein levels of CDK1 (zeige CDK1 Proteine) and its subcellular localization.
RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt (zeige AKT1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathways.
Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene.
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (zeige WNT2 Proteine) signalling through physical interactions of RARs (zeige RARS Proteine) with beta-catenin (zeige CTNNB1 Proteine).
Data show that retinoic acid receptor gamma (RARgamma)-proto-oncogene protein c-fos (c-Fos)-PPARgamma2 (PPARgamma2 (zeige PPARG Proteine)) signaling rather than reactive oxygen species generation is critical for all-trans retinoic acid (ATRA)-inhibited adipocyte differentiation.
RARgamma plays key roles in the differentiation competence of NGN3 (zeige NEUROG3 Proteine)+ cells in response to retinoic acid during mouse spermatogenesis.
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha (zeige RARA Proteine) and RARgamma in bone structure regulation.
this study shows that the combination of Rarg and Nr5a2 (zeige NR5A2 Proteine) rapidly promote the iN cell maturation within 1 week and greatly facilitate the conversion with neuronal purities of approximately 50% and yields of >130%.
Data indicate that all three retinoic acid receptor (zeige RARA Proteine) isoforms RARalha, RARbeta (zeige RARB Proteine) and RARgamma are expressed in naive CD8 (zeige CD8A Proteine)+ T cells, as well as CD8 (zeige CD8A Proteine)+ T cells activated for 48 or 72 h.
erythroid-specific RAR (zeige RARA Proteine) function is dispensable for erythropoiesis and RARgamma plays an erythroid extrinsic role in erythropoiesis.
Data indicate that male germ cell specific miR (zeige MLXIP Proteine)-34c might be pivotal in embryonic stem cells (ESCs (zeige NR2E3 Proteine)) differentiation into male germ cells through its target retinoic acid receptor gamma (RARg).
RARG cell-autonomously transduces, in undifferentiated spermatogonia of adult testes, a RA signal critical for spermatogenesis.
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
retinoic acid receptor, gamma
, retinoic acid receptor gamma-like
, retinoic acid receptor gamma
, nuclear receptor subfamily 1 group B member 3
, retinoic acid nuclear receptor gamma variant 1
, retinoic acid nuclear receptor gamma variant 2
, RAR gamma 2
, RAR-gamma 2.1
, rar gamma
, retinoic acid receptor gamma isoform 2.1