TRKA ELISA Kit

Produktnummer ABIN2042710

Produktdetails TRKA ELISA Kit

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Detektionsbereich: 6-10000 pg/mL

Untere Nachweisgrenze: 6 pg/mL

Applikation: ELISA

Marke: BioAssay™

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Sensitivität: < 10 pg/mL

Bestandteile: 96-well plate pre-coated with anti-TrkA, Human
Lyophilized recombinant TrkA, Human standard, 10 ng/tube, 2Ea
Avidin-Biotin-Peroxidase Complex (ABC), 130 µL (1:100 dilution)
Sample diluent buffer, 30 mL
Antibody diluent buffer, 10 mL
ABC diluent buffer, 10 mL
TMB color developing agent, 10 mL
TMB stop solution, 10 mL

Anwendungsinformationen

Plattentyp: Pre-coated

Protokoll: Sandwich ELISA quantitative detection kit for Human trkA in cell culture supernates, cell lysates and tissue homogenates.Tropomyosin receptor kinase A (TrkA) are efficacious in attenuating skeletal pain.1 TrkA mutants were able to activate signaling cascades and were even more efficient in promoting neurite outgrowth than the wild-type receptor.2 TrkA is part of a sub-family of protein kinases which includes TrkB and TrkC. Also, there are other neurotrophic factors structurally related to NGF BDNF (for Brain-Derived Neurotrophic Factor), NT-3 (for Neurotrophin-3) and NT-4 (for Neurotrophin-4). While TrkA mediates the effects of NGF, TrkB is bound and activated by BDNF, NT-4, and NT-3. Further, TrkC binds and is activated by NT-3.3 TrkA receptor was found in kehumanoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.4 The standard product used in this kit is extracellular part (A33-P418) of recombinant human TRKA, consisting of 386 amino acids with the molecular weight of 69kD.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C/-20 °C

Details zu TRKA

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Andere Bezeichnung: TrkA (NTRK1 Produkte)

Synonyme: MTC ELISA Kit, TRK ELISA Kit, TRK1 ELISA Kit, TRKA ELISA Kit, Trk-A ELISA Kit, p140-TrkA ELISA Kit, CDHF12 ELISA Kit, CDHR16 ELISA Kit, HSCR1 ELISA Kit, MEN2A ELISA Kit, MEN2B ELISA Kit, MTC1 ELISA Kit, PTC ELISA Kit, RET-ELE1 ELISA Kit, RET51 ELISA Kit, Trk ELISA Kit, C80751 ELISA Kit, Tkr ELISA Kit, TrkA ELISA Kit, trk ELISA Kit, trka ELISA Kit, CTRKA ELISA Kit, trkA ELISA Kit, neurotrophic receptor tyrosine kinase 1 ELISA Kit, ret proto-oncogene ELISA Kit, neurotrophic tyrosine kinase, receptor, type 1 ELISA Kit, NTRK1 ELISA Kit, RET ELISA Kit, Ntrk1 ELISA Kit, ntrk1 ELISA Kit

Gen-ID: 4914

UniProt: P04629

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process