anti-Maus STAT2 Antikörper für Enzyme Immunoassay

Recommended STAT2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antikörper
  • wu:fj84d07
  • p113
  • stat2
  • 1600010G07Rik
  • AW496480
  • ISGF-3
  • P113
  • STAT113
  • signal transducer and activator of transcription 2
  • AGAP000099-PA
  • stat2
  • STAT2
  • Stat2
Epitop
N-Term, pTyr690
45
35
18
17
15
15
12
11
11
9
8
7
7
7
6
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
258
98
81
10
3
3
2
2
2
2
1
Wirt
Kaninchen
279
19
1
Klonalität
Polyklonal
Konjugat
Dieser STAT2 Antikörper ist unkonjugiert
12
10
9
6
6
6
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
243
117
109
46
27
23
17
13
9
6
3
3
2
2
1
1
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN5551836
$ 619.30
Zzgl. Versandkosten $45.00

General

Antigen Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antikörper
Epitop N-Term, pTyr690
(45), (35), (18), (17), (15), (15), (12), (11), (11), (9), (8), (7), (7), (7), (6), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(258), (98), (81), (10), (3), (3), (2), (2), (2), (2), (1)
Wirt Kaninchen
(279), (19), (1)
Klonalität
Polyklonal
Konjugat Dieser STAT2 Antikörper ist unkonjugiert
(12), (10), (9), (6), (6), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Western Blotting (WB)
(243), (117), (109), (46), (27), (23), (17), (13), (9), (6), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-STAT2 Antikörper

Target Details STAT2 Anwendungsinformationen Handhabung Bilder
Spezifität This purified antibody is directed against STAT2 pY690 protein.
Kreuzreaktivität (Details) Species reactivity (expected):Rat, Mouse.
Species reactivity (tested):Human.
Produktmerkmale Concentration: 1.15 mg/mL (by UV absorbance at 280 nm)
Reinigung Affinity chromatography
Immunogen Synthetic peptide corresponding to a region near the N-terminus of human STAT2 protein
Isotyp IgG
Plasmids, Primers & others

Target Details STAT2

Produktdetails anti-STAT2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung STAT2 (STAT2 Antibody Abstract)
Hintergrund STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.Synonyms: Signal transducer and activator of transcription 2, p113
Gen-ID 6773
NCBI Accession NP_005410
UniProt P52630
Pathways JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events

Anwendungsinformationen

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Handhabung Bilder zurück nach oben
Applikations-hinweise ELISA: 1/85,000. Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Anwendungsinformationen Bilder zurück nach oben
Konzentration 1.15 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C