anti-Human STAT2 Antikörper für Western Blotting

Recommended STAT2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antikörper
  • wu:fj84d07
  • p113
  • stat2
  • 1600010G07Rik
  • AW496480
  • ISGF-3
  • P113
  • STAT113
  • signal transducer and activator of transcription 2
  • AGAP000099-PA
  • stat2
  • STAT2
  • Stat2
Epitop
C-Term
47
34
18
17
15
15
13
10
10
9
8
8
7
7
6
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
268
104
90
10
3
3
2
2
2
2
1
Wirt
Maus
289
19
1
Klonalität
Monoklonal
Konjugat
Dieser STAT2 Antikörper ist unkonjugiert
12
10
9
6
6
6
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
252
118
113
52
27
23
17
13
9
6
3
3
3
2
1
1
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN964699
$ 389.00
Zzgl. Versandkosten $45.00 und $23.00 Trockeneis
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
3.0650759 ABIN2705257 IHC WB Rabbit C-Term, pTyr690 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN4898094 FACS SimWes WB Rabbit IgG pTyr689 Anmelden zum Anzeigen 1021D 0
3.0650759 ABIN411595 WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN2855558 IP IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN1531245 IHC ELISA WB Rabbit IgG AA 656-705, pTyr690 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN1532263 IHC ELISA WB Rabbit IgG AA 656-705 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN393838 ELISA IF WB Mouse IgG1 kappa AA 742-851 Anmelden zum Anzeigen 5G7 0
3.0650759 ABIN1860648 ICC IHC WB Rabbit IgG AA 616-849 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN657671 IHC (p) WB Rabbit Ig Fraction AA 186-215, N-Term Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN349594 ELISA WB Rabbit IgG pTyr690, Internal Region Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN1870639 WB Rabbit IgG pTyr690 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN3043177 WB Rabbit IgG AA 796-814, C-Term Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN746183 IF (p) IHC (p) WB Rabbit IgG AA 670-720, pTyr690 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN407834 IHC (p) IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN388366 IHC (p) WB Rabbit Ig Fraction AA 820-851, C-Term Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN5692942 WB Rabbit Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN1845647 IHC WB Rabbit pTyr690 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN563025 IF ELISA WB Mouse IgG1 kappa AA 742-851, partial Anmelden zum Anzeigen 5G7 0
3.0650759 ABIN3187617 ELISA IHC (p) WB Rabbit IgG Tyr1221, Tyr1222 Anmelden zum Anzeigen Polyclonal 0
3.0650759 ABIN3187080 ELISA IHC WB Rabbit IgG Tyr1221, Tyr1222 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antikörper
Epitop C-Term
(47), (34), (18), (17), (15), (15), (13), (10), (10), (9), (8), (8), (7), (7), (6), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(268), (104), (90), (10), (3), (3), (2), (2), (2), (2), (1)
Wirt Maus
(289), (19), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser STAT2 Antikörper ist unkonjugiert
(12), (10), (9), (6), (6), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Applikation ELISA, Western Blotting (WB)
(252), (118), (113), (52), (27), (23), (17), (13), (9), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-STAT2 Antikörper

Target Details STAT2 Anwendungsinformationen Handhabung Bilder
Spezifität This Protein-A purified antibody is directed against human STAT2 protein. A BLAST analysis was used to suggest cross-reactivity with STAT2 protein from human, rat (73%) and mouse (76%), sources based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Produktmerkmale STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.
Sterilität Sterile filtered
Immunogen This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus of mouse STAT2 protein.
Immunogen Type: Peptide
Klon 19G8-H2-H6
Isotyp IgG2a kappa
Plasmids, Primers & others

Target Details STAT2

Produktdetails anti-STAT2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung STAT2 (STAT2 Antibody Abstract)
Hintergrund STAT2 is a member of the STAT family of transcription factors.  Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex.  This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription.  Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation.  IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment.  Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha.  Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer.  From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.
Synonyms: Stat2, Signal transducer and activator of transcription 2, p113
Gen-ID 6773, 4885615
UniProt P52630
Pathways JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events

Anwendungsinformationen

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Handhabung Bilder zurück nach oben
Applikations-hinweise This Protein-A purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 113 kDa in size corresponding to STAT2 protein by western blotting in the appropriate cell lysate or extract.
Kommentare

Gene Name: STAT2

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Haltbarkeit 12 months

Bilder

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term) antibody (ABIN964699) anti-Stat2 monoclonal antibody was used at a 2.5 µg/mL to detect Stat2 in squamous ep...
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term) antibody (ABIN964699) anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term) antibody (Image 2)
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term) antibody (ABIN964699) HeLa whole cell lysate was loaded at 1 µg. The blot was blocked with 1% BSA in TBST f...
 image for anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term) antibody (ABIN964699) anti-Stat2 monoclonal antibody was used at a 2.5 µg/mL to detect Stat2 in squamous ep...