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Socs1a transgenic zebrafish have liver steatosis and insulin (zeige INS Proteine) resistance.
Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (zeige JAK2 Proteine)-Stat5 (zeige STAT5B Proteine) pathway.
in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (zeige SOCS3 Proteine) proteins.
SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.
The upregulation of SOCS-1 and SOCS-2 (zeige SOCS2 Proteine) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
Co-immunoprecipitation experiments showed that SOCS1 mutations abolished JAK3 (zeige JAK3 Proteine) binding, revealing a key role for SOCS1 in regulating JAK3 (zeige JAK3 Proteine)/STAT5 (zeige STAT5A Proteine) signaling
C/EBPbeta (zeige CEBPB Proteine) overexpression or knockdown did not change the levels of IL-1beta (zeige IL1B Proteine)-induced SOCS1. SOCS1 regulated the levels of C/EBPbeta (zeige CEBPB Proteine) mRNA by ubiquitination of C/EBPbeta (zeige CEBPB Proteine) as well as transcriptional regulation in human chondrocytes.
patients with renal graft rejection expressed lower levels of SOCS1
Inhibiting the STAT3 (zeige STAT3 Proteine)-Mcl-1 (zeige MCL1 Proteine) signaling axis by ectopic SOCS1 improved radiosensitivity by inducing apoptosis and enhancing DNA damage after radiotherapy, offering a mechanistic rationale for a new esophageal squamous cell carcinoma treatment.
an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene (zeige RAB1A Proteine).
MiRNA sponges against miR (zeige MLXIP Proteine)-19 or miR (zeige MLXIP Proteine)-155 inhibit the functions of these miRNAs and potentiate the induction of SOCS1 and p53 (zeige TP53 Proteine) in mouse leukemia cells and in human myeloma cells.
Mutations of CREBBP (zeige CREBBP Proteine) and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma; SOCS1 mutations were associated with better progression-free survival.
These results suggest that miR146a may regulate SOCS1/STAT3 (zeige STAT3 Proteine) and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection.
IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 (zeige SOCS3 Proteine) or USP18 (zeige USP18 Proteine).
This study evaluation the roles of SOCS1, the regulator of TLR9 (zeige TLR9 Proteine), RIG-I (zeige DDX58 Proteine), and CD152 (zeige CTLA4 Proteine) in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported.
these findings suggest that SOCS-1 may exert its protective effect in acute lung injury by rescuing epithelial sodium channel alpha-subunit (zeige SCNN1A Proteine) expression via suppression of ASK-1 (zeige MAP3K5 Proteine).
loss of SOCS1 in CD11c (zeige ITGAX Proteine)+ cells skewed the balance of immune response to infection by increasing innate responses while decreasing antigen-specific adaptive responses to infectious antigens
Study conclude that under pro-proliferative cytokine stimulation at the onset of myeloproliferative diseases SOCS1 acts as a tumor suppressor, while under anti-proliferative conditions it exerts oncogenic function.
results indicate that SOCS1 is one of the essential molecules that maintain regulatory T cell stability, particularly under the inflammatory conditions in which APCs (zeige APCS Proteine) are highly activated
The Stat3 (zeige STAT3 Proteine) exerts its activity through the induction of miR (zeige MLXIP Proteine)- 155, which suppresses suppressor of cytokine signaling (SOCS (zeige CISH Proteine))1.
Cell type-specific, different roles for viral immediate early (zeige JUN Proteine) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 and SOCS3 (zeige SOCS3 Proteine) during murine cytomegalovirus infection.
Loss of SOCS3 (zeige SOCS3 Proteine) significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 deficiency. We propose a model in which SOCS1 and SOCS3 (zeige SOCS3 Proteine) operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease
miR (zeige MLXIP Proteine)-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT (zeige STAT1 Proteine) and PDCD4 (zeige PDCD4 Proteine), as well as the production of proinflammation mediators IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) in atherogenesis.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
suppressor of cytokine signaling 1
, suppressor of cytokine signalling
, suppressor of cytokine signaling 1b
, suppressor of cytokine signaling 1-like protein
, JAK binding protein
, JAK-binding protein
, STAT induced SH3 protein 1
, STAT-induced STAT inhibitor 1
, Tec-interacting protein 3
, cytokine-inducible SH2 protein 1
, JAK2-binding protein
, cytokine inducible SH2-containing protein 1
, cytokine inducible SH2-containing protein 7