anti-Human IL2RG Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended IL2RG Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 2 Receptor, gamma (IL2RG) Antikörper
  • Ab2-183
  • Cd132
  • CD132
  • CIDX
  • IL-2RG
  • IMD4
  • P64
  • SCIDX
  • SCIDX1
  • [g]c
  • gamma(c)
  • gc
  • interleukin 2 receptor subunit gamma
  • interleukin 2 receptor subunit gamma L homeolog
  • interleukin 2 receptor, gamma chain
  • IL2RG
  • il2rg.L
  • Il2rg
Epitop
AA 135-185
14
11
10
10
9
8
8
7
7
5
4
4
4
4
3
2
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
132
77
27
3
1
Wirt
Kaninchen
100
41
29
2
Klonalität
Polyklonal
Konjugat
Dieser IL2RG Antikörper ist unkonjugiert
12
9
9
6
5
5
5
5
5
4
4
4
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
75
73
49
19
12
7
6
5
4
3
2
2
1
1
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN2176981
$ 306.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2814780 IF (p) Alexa Fluor 594 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176991 IF (p) FITC Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176990 IF (p) Cy7 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176987 IF (p) Cy3 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176988 IF (p) Cy5 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176989 IF (p) Cy5.5 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176983 IF (p) Alexa Fluor 488 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176985 IF (p) Alexa Fluor 647 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176984 IF (p) Alexa Fluor 555 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2176982 IF (p) Alexa Fluor 350 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5005333 IF (p) Alexa Fluor 680 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5005334 IF (p) Alexa Fluor 750 Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interleukin 2 Receptor, gamma (IL2RG) Antikörper
Epitop AA 135-185
(14), (11), (10), (10), (9), (8), (8), (7), (7), (5), (4), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(132), (77), (27), (3), (1)
Wirt Kaninchen
(100), (41), (29), (2)
Klonalität
Polyklonal
Konjugat Dieser IL2RG Antikörper ist unkonjugiert
(12), (9), (9), (6), (5), (5), (5), (5), (5), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(75), (73), (49), (19), (12), (7), (6), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL2RG Antikörper

Target Details IL2RG Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IL-2R gamma
Isotyp IgG
Plasmids, Primers & others

Target Details IL2RG

Produktdetails anti-IL2RG Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Il-2r gamma (IL2RG Antibody Abstract)
Hintergrund

Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.

Subcellular location: Extracellular

Synonyms: P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, gammaC, IL2RG

Gen-ID 3561
UniProt P31785
Pathways JAK-STAT Signalweg, Growth Factor Binding

Anwendungsinformationen

Produktdetails anti-IL2RG Antikörper Target Details IL2RG Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL2RG Antikörper Target Details IL2RG Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-IL2RG Antikörper Target Details IL2RG Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Immunofluorescence (IF) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin-embedded human lung labeled with Anti-IL-2R gamma Polyclo...
Western Blotting (WB) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) L1 rat spleen lysates L2 mouse heart lysates probed with Anti IL-2R gamma/CD132 Polyc...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Flow Cytometry (FACS) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Human U937 cells probed with IL-2R gamma Polyclonal Antibody, Unconjugated (green) a...