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Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN988042
Suzuki, McCall, Choi, Sicklick, Huang, Qi, Zdanowicz, Camp, Li, Diehl: Interleukin-15 increases hepatic regenerative activity. in Journal of hepatology 2006
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T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (zeige CD3 Proteine)(-) CD8 (zeige CD8A Proteine)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (zeige IFNG Proteine), and that IL-15 elicits IFN-gamma (zeige IFNG Proteine) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (zeige CD8A Proteine) antigen, IFN-gamma (zeige IFNG Proteine)]
an IL-15 isoform lacking exon-6, IL-15DeltaE6, generated by alternative splicing events of activated immune cells, including macrophages and B cells, is reported.
IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes.
These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated allergic airway disease, which can be regulated by CD8 (zeige CD8A Proteine)(+) T cells.
IL-15 induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 is associated with the development of important side effects mainly mediated by IFN-gamma (zeige IFNG Proteine)-producing T-cells
findings indicated that IL-15 plays an important role in preventing leukemia development.
NK cells activated by IL-4 (zeige IL4 Proteine) in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
Genetic ablation of the IL2Rbeta chain on CD8 (zeige CD8A Proteine)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (zeige CD244 Proteine) and Tim-3 (zeige HAVCR2 Proteine); precludes terminal differentiation of highly defective PD-1 (zeige PDCD1 Proteine)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (zeige IL7 Proteine)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 (zeige IL2 Proteine) and IL-15 as instigators of CD8 (zeige CD8A Proteine)(+) T-cell exhaustion during chronic viral infe...
aerobic interval training enhanced the anti-inflammatory indices IL-10 (zeige IL10 Proteine)/TNF-alpha (zeige TNF Proteine) ratio and IL-15 expression in skeletal muscle in tumor-bearing mice.
this study reveals the function of IL-15 in astrocyte survival via Akt (zeige AKT1 Proteine) phosphorylation in response to OGD (zeige FGFR1 Proteine)-induced damage.
Our new compelling findings have established the critical roles of both IL-7 (zeige IL7 Proteine) and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 (zeige IL7 Proteine) and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.
These data suggest that TLR2 activation is involved in the induction of IL-15 production by primary Sjogren's syndrome salivary gland epithelial cells and promotes inflammation through NF-kappaB (zeige NFKB1 Proteine) activation.
Transgenic expression of IL15 is an appealing strategy to enhance CAR T-cell effector function. We tested this approach in our IL13Ralpha2-positive glioma model in which limited IL13Ralpha2-CAR T-cell persistence results in recurrence of antigen-positive gliomas. T cells were genetically modified with retroviral vectors encoding IL13Ralpha2-CARs or IL15 (IL13Ralpha2-CAR.IL15 T cells).
PLX4032, a selective BRAF (zeige BRAF Proteine)-i, has no inhibitory effect either on NK cell proliferation in response to cytokines IL-2 (zeige IL2 Proteine) or IL-15
this review will focus on IL-15 biology in NK cells and proposes the development novel therapies aimed at this pathway in humans
IL-15 levels were found to be elevated in depressed patients with asthma.
this paper show that IL-15 boosts the function and migration of human terminally differentiated CD8 (zeige CD8A Proteine)+ T cells by inducing a unique gene signature
inhibits the Ca(2 (zeige CA2 Proteine)+)-induced differentiation of keratinocytes, mainly via the attenuation of Ca(2 (zeige CA2 Proteine)+)-stimulated PI3K (zeige PIK3CA Proteine)-AKT (zeige AKT1 Proteine) signalling
The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33 (zeige CD33 Proteine)(+) HL-60 targets and increased NK survival and proliferation.
In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway.
n this study, authors compared the concentrations of IL-15 and IL-7 (zeige IL7 Proteine) in the plasma of MDS (zeige PAFAH1B1 Proteine) patients (n = 20) compared with that in the plasma of healthy controls (n = 20). Results indicated that exposure to high levels of IL-15 may be involved in the T cell phenotype conversion observed in MDS (zeige PAFAH1B1 Proteine).
Study identified two completely linked SNPs in the porcine IL15 promoter region that could alter IL15 transcription activity. As interleukin-15 can inhibit porcine adipocyte differentiation, these promoter mutations could affect intramuscular fat deposition by producing differential levels of muscle-derived interleukin-15.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (zeige FYN Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathways
IFN-gamma (zeige IFNG Proteine) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (zeige IFNG Proteine) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (zeige BCL2 Proteine).
IL 15 generates a dramatic expansion of short-lived memory CD8 (zeige CD8A Proteine) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (zeige CD4 Proteine) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (zeige CD4 Proteine) on memory CD4 (zeige CD4 Proteine) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.